| 2型糖尿病患者FAT／CD36基因启动子区-3489C／T和密码子区478C／T多态性研究 |
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| 引用本文： | 曾蓉,严新民,宋滇平,高建梅.2型糖尿病患者FAT／CD36基因启动子区-3489C／T和密码子区478C／T多态性研究[J].中华临床医师杂志(电子版),2008,2(3):16-19. |
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| 作者姓名： | 曾蓉 严新民 宋滇平 高建梅 |
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| 作者单位： | [1]昆明医学院第一附属医院糖尿病科,650031; [2]云南省第一人民医院基础医学研究所,650031; |
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| 摘 要： | 目的探讨FAT／CD36脂肪酸转位酶基因启动子区-3489C／T和密码子区478C／T多态性与2型糖尿病（T2DM）的相关性。方法运用聚合酶链反应-限制性片段长度多态性技术对196例T2DM患者和120例正常对照者的-3489C／T与478C／T多态性进行检测，并比较各组间基因型频率和等位基因频率以及相关临床资料。结果（1）所有研究对象均无一例存在FAT／CD36基因启动子区478C→T突变，基因型均表现为478CC之纯合子，478CC和478TT等位基因频率分别为1和0。（2）T2DM组和正常对照组的-3489C／T多态性基因型和等位基因频率比较差异无统计学意义，P值分别为0．682和0．683。结论昆明地区的汉族人中FAT／CD36基因的启动子区一3489C／T和密码子区478位C／T多态性与昆明地区汉族人群2型糖尿病的发生无显著相关关系。
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| 关 键 词： | 糖尿病 2型 多态现象 遗传 脂肪酸转位酶 |
Correlation between fatty acid translocase gene polymorphism and Chinese type 2 diabetes mellitus |
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| ZENG Rong,YAN Xin-min,SONG Dian-ping,GAO Jian-mei.Correlation between fatty acid translocase gene polymorphism and Chinese type 2 diabetes mellitus[J].Chinese Journal of Clinicians(Electronic Version),2008,2(3):16-19. |
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| Authors: | ZENG Rong YAN Xin-min SONG Dian-ping GAO Jian-mei |
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| Affiliation: | ZENG Rong, YAN Xin-min, S0NG Dian-ping , GA0 Jian-mei. (Diabetic Department, The First Affiliated hospital of Kunming Medical College, Kunming 650031, China) |
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| Abstract: | Objective To study the correlation between fatty acid translocase （FAT/CD36） gene promoter region -3489C/T and code region 478C/T polymorphism and type 2 diabetes mellitus. Methods -3489C/T and 478C/T polymorphism were screened in 196 type 2 diabetic patients and 119 normal controls by polymerase chain reaction restriction fragment lenth polymorphism method （PCR-RFLP）. Results （ 1 ） All subjects proved to be homozygote wildtypes （CC） for the 478C→T substitution. （ 2 ） No significant differences were found in alleles and genotype frequencies of FAT/CD36 gene-3489C/T polymorphism between diabetic patients and non-diabetic contronls. Conclusions FAT/CD36 gene-3489C/T or 478C/T polymprphism was not significantly associated with type 2 diabetes mellitus in Han people of Yunnan. |
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| Keywords: | Diabetes mellitus Type 2 Polymorphism Genetic Fatty acid translocase |
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