| 核磁共振跟踪反应法研究5—O—乙酰基—2.3-双脱氧-D.L-呋喃戊糖基氯的合成 |
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| 引用本文： | 艾克蕙,李英富,弋昌厚,吴玉蓉.核磁共振跟踪反应法研究5—O—乙酰基—2.3-双脱氧-D.L-呋喃戊糖基氯的合成[J].四川大学学报(自然科学版),1993(1). |
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| 作者姓名： | 艾克蕙 李英富 弋昌厚 吴玉蓉 |
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| 作者单位： | 四川大学化学系
(艾克蕙，李英富，弋昌厚)，四川大学化学系(吴玉蓉) |
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| 摘 要： | 以乙酸四氢呋喃甲酯为原料,通过自由基氯化反应,合成双脱氧核苷类抗艾滋病药物的重要中间体化合物5—0—乙酰基—2.3—双脱氧—D.L—吹喃戊糖基氯.对于此种不稳定的中间体化合物,用~1HNMR跟踪监测反应物的方法,研究了改变反应时间、反应温度和反应物摩尔比对反应产物的影响,获得了最佳的反应条件,使其收率从10％提高到50％左右.
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| 关 键 词： | ~2HNMR 双脱氧核苷 |
STUDIES ON THE SYTHESIS OF 5-O-ACETYL-2,3-DBDEOXY-D, L-RIBOFURANOYL CHLORIDE BY USING NMR |
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| Ai Kehia Li Yingfu Yi Changhou Wu Yurong.STUDIES ON THE SYTHESIS OF 5-O-ACETYL-2,3-DBDEOXY-D, L-RIBOFURANOYL CHLORIDE BY USING NMR[J].Journal of Sichuan University (Natural Science Edition),1993(1). |
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| Authors: | Ai Kehia Li Yingfu Yi Changhou Wu Yurong |
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| Affiliation: | Department of Chemistry |
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| Abstract: | 5 - 0 - acetyl - 2,3 - dideoxy - D, L - pentofuranoyl Chloride, which is an important intermediate of 2,3 - dideoxy nucleosides, has been prepared by radical Chlorination of tetrahydrofurfuryl acetate. The effects of the reaction time, temperature and molar ratio of the reactants on the products were investigated. The yield of 5 - 0 - acetyl - 2. 3 -dideoxy -D. L -pentofuranoyl chloride increased from 10% to 50 % according to the optimum reaction conditions found by H NMR. |
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| Keywords: | 1~H NMR dideoxynucleoside 5 - 0 - acety1 - 2 3 - dideoxy - D L-pentofuranoyl Chloride |
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