HAI-1与妇科恶性肿瘤的研究进展

妇科恶性肿瘤严重威胁女性健康,已逐渐成为重大公共健康问题,从而引起广泛的重视。其中,女性肿瘤中三大肿瘤的发病率也位居全国恶性肿瘤发病率的前十位,并且其发病率和死亡率呈逐年上升趋势。由于肿瘤的发生、发展是一个多因素、多步骤的复杂过程,因此控制其发生、发展极为重要。肝细胞生长因子激活物抑制因子(HAI)基因是一种位于15号染色体上的内源性抑制因子,主要生理功能是抑制肝细胞生长因子激活物、丝氨酸蛋白酶等体内生物酶的活性。近年来有众多学者发现HAI-1与恶性肿瘤生长抑制有关,同时发现在妇科恶性肿瘤的发生、发展、浸润、转移、分化以及肿瘤血管形成中HAI-1发挥重要作用。

The Research Progress of HAI-1 and Gynecologic Malignant Tumor

Female health are being severe threatened by gynecological malignant tumors. It has become a major public health problem in China and has drawn extensive attention consequently. The incidence of three large tumors in female tumors stands top ten among all kinds of tumors in China. The morbidity and mortality are rising year by year. The tumors′development and progression are a multi-factor and multi-step process, so it is very important to control the occurrence and development of tumor. Hepatocyte growth factor activator inhibitor (HAI) gene is a kind of endogenous suppressor genes, which is located on chromosome 15. Its main physiological function is to restrain the activity of enzymes in bodies ,such as serine protease, hepatocyte growth factor activator and so on. Many experts found that HAI-1 could restrain the malignant tumors growth, they also found that HAI-1 could play an important part on the occurrence, development, infiltration, metastasis and tumor angiogenesis of gynecologic malignant tumors.