| 慢性阻塞性肺疾病患者血清细胞因子的变化及其临床意义 |
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| 引用本文： | 朱斌,郝建,王伟,程曦,黄鹤,沈亚伟.慢性阻塞性肺疾病患者血清细胞因子的变化及其临床意义[J].临床肺科杂志,2008,13(12):1570-1571. |
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| 作者姓名： | 朱斌 郝建 王伟 程曦 黄鹤 沈亚伟 |
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| 作者单位： | 安徽省合肥市解放军105医院,230031 |
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| 摘 要： | 目的探讨研究COPD患者血清CK-MB、NO、IL-6、TNF-α的含量变化及临床意义。方法选A组38例患者及B组35例患者，测定其患者治疗前后的血清CK—MB、NO、IL-6、TNF-α的含量。结果A组患者血清CK—MB、NO、IL6、TNF-α的浓度明显高于B组患者P〈0．01）。治疗后，A组患血清CK-MB、NO、IM、TNF-α的浓度较治疗前明显下降（P〈0．01）。结论当COPD患者伴心力衰竭时，炎性细胞因子可显著升高，参与心肌损害，心肌收缩力减弱导致心衰作用。
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| 关 键 词： | 慢性阻塞性疾病 充血性心力衰竭 肌酸激酶心肌同工酶 一氧化氮 白细胞介素-6 肿瘤坏死因子 |
The study on changes and clinical significance of serum of cell factors in patients with chronic obstructive pulmo-nary disease with respiratory failure |
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| Affiliation: | Zhu Bin, HaoJian, Wang Wei, et al. (Department of Pulmonale, 105th Hospital of PLA, Hefei, Anhui,230031, China) |
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| Abstract: | Objective To explore the changes and clinical significance of CK-MB, NO, IL-6 and TNF-α in A group. Methods Before and after treatment, serum CK-MB, NO, IL-6 and TNF-α concentrations were measured by 38cases of A group and 35 cases of B group. Results The concentrations of serum CK-MB, NO, IL-6 and TNF-α in A group were significantly higher than B group before treatment （P 〈 O. O1 ） ; the concentrations of serum CK-MB, NO, IL-6 and TNF-α of the patients were more reducible in A group after treatment （P 〈 0.01 ）. Conclusions There are excessive release of inflammatory cytokine and cardiac muscle damage in A group. |
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| Keywords: | COPD congestive heart failure CK-MB NO IL-6 TNF-α |
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