中医药治疗老年脑梗死患者抑郁症状与血液流变学改变的关系

目的:观察中医药治疗老年脑梗死患者抑郁症状与血液流变学改变的关系。方法:收集42例老年脑梗伴抑郁症状患者分别于中医药治疗前和3周后进行血液流变学检测和比较,同时评定汉密尔顿抑郁量表(HAMD),并与40例老年脑梗不伴抑郁症状患者及40例健康老人进行对照。结果:①入组时老年脑梗死患者的抑郁症状(HAMD量表分)全血黏度(120s-1、70 s-1和30 s-1)、与全血还原黏度(高切、中切和低切)、血浆黏度、红细胞聚集指数、红细胞压积等指标都呈显著正相关(P0.05～0.01);②伴抑郁组42例(HAMD总分17分)与40例不伴发者比较,伴发组的全血黏度(120s-17、0 s-1和50 s-1)、全血还原黏度(高切、中切和低切)、血浆黏度、红细胞压积等指标都显著高于对照(非伴发组和健康组,P0.01),通过中医药治疗后这种差异减轻甚至消失(P0.05～0.01);③伴抑郁组全血黏度(120 s-17、0s-1和30s-1)、与全血还原黏度(高切、中切和低切)、红细胞聚集指数、红细胞压积等指标经中医药治疗3周的变化值与抑郁量表的减分值呈显著正相关(P0.05～0.01)。结论:老年脑梗死患者抑郁症状与血液流变学改变的关系密切,伴抑郁症状的老年脑梗患者的高黏滞血症更突出,其高黏滞的程度与抑郁症状平行,通过动态观察血液流变学改善情况与疾病好转相关程度,为中医药治疗老年脑梗死患者抑郁症状的疗效提供了现代科学依据。

TCM Therapy For Elderly Patients With Cerebral Infarction Depressive Symptoms And The Relationship Between The Change Of Bloodrheology

Objective: To observe the TCM therapy in elderly patients with cerebral infarction depressive symptoms and the relationship between the change of blood rheology.Methods: We collected 42 patients with cerebral infarction with elderly patients with symptoms of depression in TCM therapy respectively before and after three weeks were measured and compared,while Hamilton depression rating scale(HAMD),and with 40 patients with cerebral infarction and not elderly patients with symptoms of depression and 40 patients with comparing the healthy old man.Results: ①When the elderly patients with cerebral infarction of the depression symptoms(HAMD scale points) whole blood viscosity(120 s-1,70 s-1 and 30 s-1),and whole blood viscosity(high cut,reduction in low shear cut and red),plasma viscosity,gathered index,RBC deposited as indexes are positively correlated(P<0.05~0.01).②With depression group 42 cases(total HAMD>17 points) and 40 patients without comorbid recipients compared,comorbid group of whole blood viscosity(120s-1,70 s-1 and 50 s-1),whole blood viscosity(high cut,reduction in low shear cut and red),plasma viscosity,such as deposited index are significantly higher than control(not comorbid group and healthy group,P<0.01),through the TCM therapy to reduce and disappeared after this difference(P<0.05 ~ 0.01).③With depression group of whole blood viscosity(120 s-1,70 s-1 and 30s-1),and whole blood viscosity(high cut,reduction in low shear),cut and gathered index,red indices such as deposited by the changes of TCM therapy for 3 weeks of value and the depression scale score reduction is a significant positive correlation(P<0.05~0.01).Conclusion: The elderly patients with cerebral infarction depressive symptoms and the change of blood rheology,close relations with depressive symptoms of and patients with cerebral infarction sticking sluggish blood disease is more outstanding,its high viscous parallel degree and depressive symptoms,through dynamic observation hemorheology improve conditions and diseases related degree,better for TCM therapy in patients with cerebral infarction depressive symptoms and the curative effect of modern scientific basis was provided.