| 3(5)-氨基吡唑-4-甲酸乙酯的合成研究 |
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| 引用本文： | 蒋华江,孙日勇,蔡继平.3(5)-氨基吡唑-4-甲酸乙酯的合成研究[J].化工时刊,2005,19(3):12-13. |
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| 作者姓名： | 蒋华江 孙日勇 蔡继平 |
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| 作者单位： | 台州学院生命科学与医药化工学院,浙江,临海,317000;临海市同丰化工厂,浙江,临海,317000 |
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| 基金项目： | 2 0 0 3年台州市第一批科技计划资助项目 (编号 :0 31 91 2 ) |
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| 摘 要： | 以乙氧亚甲基氰乙酸乙酯和水合肼为原料，考察了溶剂、温度以及原料配比对产率的影响，确定了初步的反应条件，所得的3(5)-氨基吡唑-4-甲酸乙酯，产率达到了85％；并用岛津FTIR-8400型红外分光光度计和NMR-500型核磁共振仪进行结构表征，WATERS-600E型HPLC测定含量。本实验具有产率高、溶剂易回收、温度易控制等优点。
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| 关 键 词： | 乙氧亚甲基氰乙酸乙酯 水合肼 3(5)-氨基吡唑-4-甲酸乙酯 合成 |
| 修稿时间： | 2004年10月26 |
Synthesis of Ethyl-3(5)-Aminopyrazole-4-Carboxylate |
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| Jiang Huajiang,Sun Riyong,Cai Jiping.Synthesis of Ethyl-3(5)-Aminopyrazole-4-Carboxylate[J].Chemical Industry Times,2005,19(3):12-13. |
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| Authors: | Jiang Huajiang Sun Riyong Cai Jiping |
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| Affiliation: | Jiang Huajiang Sun Riyong Cai Jiping* |
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| Abstract: | Ethyl-3(5)-aminopyrazole-4-carboxylate was synthesized with ethyl ethoxymethylenecyanoacetate and hydration hydrazine.The influence of the solvent?temperature and raw materials mixing on the product yield was observed.The preliminary reaction conditions were defermined and the product yield was 88.39%.The product was characterized with FTIR-8400,HPLC WATERS-600 E type and 500MHZ Bruker spectrometer.This experiment has many merits:high yield,reuse of solvent and easy control of temperature. |
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| Keywords: | ethylethoxymethylenecyanoacetate hydrazinehydrate ethyl-3(5)-aminopyrazole-4-Carboxylate synthesis |
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