半夏泻心汤加减治疗慢性萎缩性胃炎脾胃湿热证临床研究

目的:评价半夏泻心汤加减治疗脾胃湿热证慢性萎缩性胃炎的临床疗效及安全性。方法: 将100例脾胃湿热证慢性萎缩性胃炎患者,按照随机数字表法分为观察组和对照组各50例。比较两组患者研究前后主要中医证候积分、血清指标变化(IL-2、IL-6、G-17、ET、EGF)、证候临床疗效、HP清除率及不良反应发生率。 结果: 两组患者在治疗12周后主要中医证候积分均有所下降,观察组治疗后证候积分明显低于对照组; 两组患者治疗后胃泌素G-17较前明显升高,且观察组明显高于对照组; IL-2及IL-6、EGF、ET均较前明显降低,且观察组明显低于对照组; 比较证候临床疗效,对照组总有效率为72.0%,观察组总有效率为88.0%,观察组证候临床疗效明显优于对照组; 以上差异均有统计学意义(P<0.05)。观察组有89.1%患者HP转阴,对照组为77.3%,观察组HP清除率较对照组高; 观察组不良反应发生率为2.0%,对照组为6.0%; 以上差异均无统计学意义(P>0.05)。结论: 半夏泻心汤可提高脾胃湿热证CAG患者机体免疫功能,改善胃黏膜炎性反应,并改善患者的临床证候。

Clinical efficacy and safety evaluation of Banxia Xiexin decoction in the treatment of chronic atrophic gastritis of spleen-stomach damp-heat type

Objective:To evaluate the clinical efficacy and safety of Banxia xiexin decoction in the treatment of chronic atrophic gastritis of spleen-stomach damp-heat type.Methods:100 patients with chronic atrophic gastritis of spleen-stomach damp-heat type of our hospital were divided into observation group and control group with 50 cases each according to the random number table method.Before and after the study,the changes of main TCM syndrome score,serum indexes(IL-2,IL-6,G-17,ET,EGF),clinical efficacy of syndrome,clearance rate of HP and incidence of adverse reactions were compared between the two groups.Results:After 12 weeks of treatment,the main TCM syndrome scores of the two groups were decreased,and the syndrome scores of the observation group were significantly lower than that of the control group;After treatment,gastrin G-17 were significantly higher in the observation group than in the control group;IL-2,IL-6,EGF and ET were significantly lower in the observation group than in the control group;The total effective rate was 72.0%in the control group and 88.0%in the observation group.The clinical efficacy of the observation group was significantly better than that of the control group.The above differences were statistically significant(P<0.05).89.1%of the patients in the observation group turned negative,while in the control group was 77.3%.The clearance rate of HP in the observation group was higher than that in the control group;The incidence of adverse reactions was 2.0%in the observation group and 6.0%in the control group.The above differences were not statistically significant(P>0.05).Conclusion:Banxia Xiexin decoction can improve the immune function of CAG patients of spleen-stomach damp-heat type,improve the gastric mucositis reaction and improve the clinical syndrome of CAG patients.