| 旋覆代赭汤对混合性反流性食管炎模型大鼠PCNA表达的影响 |
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| 引用本文： | 唐丽明,曹丽霞,袁红霞,杨幼新,魏爱勤.旋覆代赭汤对混合性反流性食管炎模型大鼠PCNA表达的影响[J].上海中医药杂志,2009,43(2). |
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| 作者姓名： | 唐丽明 曹丽霞 袁红霞 杨幼新 魏爱勤 |
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| 作者单位： | 唐丽明,TANG Li-ming(天津中医药大学2007级博士生,天津,300193);曹丽霞,CAO Li-xia(天津中医药大学2006级硕士生,天津,300193);袁红霞,YUAN Hong-xia(天津中医药大学保康医院,天津,300193);杨幼新,YANG You-xin(天津中医药大学国际学院,天津,300193);魏爱勤,WEI Ai-qin(天津市南开区中医医院,天津,300123)
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| 基金项目： | 国家自然科学基金，天津市卫生局基金 |
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| 摘 要： | 目的观察旋覆代赭汤对混合性反流性食管炎模型大鼠食管黏膜组织增殖细胞核抗原(PCNA)表达的影响。方法采用"食管十二指肠端侧吻合术"制作动物模型。80只大鼠随机分为正常对照组、模型组、中药(旋覆代赭汤)治疗组、西药(莫沙必利)对照组,给予相应处理或用药后,取食管组织行HE染色,用免疫组化的方法测其PCNA的表达。结果旋覆代赭汤能显著抑制反流性食管炎模型大鼠PCNA表达的升高,与模型组相比PCNA的表达率显著降低(P<0.01),其疗效与西药组相当,与正常组相比亦无显著性差异(P>0.01)。结论旋覆代赭汤可明显降低混合性反流性食管炎食管黏膜PCNA的高表达,并能抗食管反流,从而起到治疗混合性反流性食管炎、预防复发及癌变的作用。
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| 关 键 词： | 旋覆代赭汤 混合性反流性食管炎 增殖细胞核抗原 实验研究 |
Effects of "Xuanfu Daizhe Decoction" on Proliferating Cell Nuclear Antigen in Rats of Mixed Reflux Esophagitis |
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| TANG Li-ming CAO Li-xia YUAN Hong-xia YANG You-xin WEI Ai-qin . Doctoral C,idate,Tianjin University of Traditional Chinese Medicine. Postgraduate,Tianjin University of Traditional Chinese Medicine.Effects of "Xuanfu Daizhe Decoction" on Proliferating Cell Nuclear Antigen in Rats of Mixed Reflux Esophagitis[J].Shanghai Journal of Traditional Chinese Medicine,2009,43(2). |
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| Authors: | TANG Li-ming CAO Li-xia YUAN Hong-xia YANG You-xin WEI Ai-qin Doctoral C idate Tianjin University of Traditional Chinese Medicine Postgraduate Tianjin University of Traditional Chinese Medicine |
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| Affiliation: | TANG Li-ming1 CAO Li-xia2 YUAN Hong-xia3 YANG You-xin4 WEI Ai-qin5 1.2007 Doctoral C,idate,Tianjin University of Traditional Chinese Medicine2.2006 Postgraduate,Tianjin University of Traditional Chinese Medicine3.Baokang Hospital of Tianjin University of Traditional Chinese Medicine4.School of International Education,Tianjin University of Traditional Chinese Medicine5.TCM Hospital of Nankai District,Tianjin |
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| Abstract: | Objective To observe the effects of "Xuanfu Daizhe Decoction" on proliferating cell nuclear antigen(PCNA)in rats of mixed reflux esophagitis.Methods Rat model was made by esophagoduodenostomy.Eighty rats were randomized into normal group,model group,herb group and mosapride group,and then treated with corresponding methods.The esophageal tissues were stained and the PCNA expression was detected by immuno-histochemical method.Results "Xuanfu Daizhe Decoction" could suppress PCNA expression(P<0.01),similar to... |
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| Keywords: | "Xuanfu Daizhe Decoction" mixed reflux esophagitis proliferating cell nuclear antigen experimental research |
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