维生素A 对2 型糖尿病大鼠模型胰岛纤维增生的影响 |
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引用本文: | 佘玉清,龚卫娟,余江毅.维生素A 对2 型糖尿病大鼠模型胰岛纤维增生的影响[J].实验动物科学,2015,32(4):17-20. |
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作者姓名: | 佘玉清 龚卫娟 余江毅 |
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摘 要: | 摘要: 目的观察维生素A 对2 型糖尿病( T2DM) 大鼠胰岛纤维增生的影响。方法维生素A 补充2 周后,将GK大鼠胰腺石蜡切片行HE 和Masson 染色,观察胰岛纤维化区域变化。结果补充维生素A 组GK ( Goto-Kakizaki)大鼠胰岛纤维增生区域明显减少。结论外源性给予维生素A 能显著减少T2DM 胰岛纤维增生。
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关 键 词: | 2 型糖尿病 胰岛纤维增生 维生素A GK 大鼠 |
Effect of Vitamin A on Islet Fibrois in Type 2 Diabetes Mellitus Animal Model |
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Abstract: | Abstract: Objective To observe the effect of Vitamin A on the islet fibrosis in type 2 diabetes mellitus ( T2DM)animal model of GK ( Goto-Kakizaki) rat. Method After administration of Vitamin A for 2 weeks; and the changes of islet fibrotic area were recorded. 5 μm serial paraffin sections of 4 months old GK rat pancreas were obtained and stained by H&E and Masson staining. Result Masson staining showed that the area of islet fibrosis staining in GK rats were significantly decreased after administration of Vitamin A compared with control group ( 44. 46 ± 16. 98 vs. 60. 22 ± 31. 47 μm2 ) . Conclusion Our study indicated that Vitamin A could significantly decrease islet fibrosis in GK rat. |
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Keywords: | type 2 diabetes mellitus islet fibrosis proliferation Vitamin A Goto-Kakizaki rat |
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