炔雌醇环丙孕酮联合二甲双胍治疗多囊卵巢综合征80例临床分析

目的 观察炔雌醇环丙孕酮（达英-35）联合二甲双胍治疗多囊卵巢综合征（PCOS）的临床效果.方法 将160例PCOS患者按随机数字表法分为观察组与对照组,每组80例.对照组给予达英-35治疗,观察组给予达英-35联合二甲双胍治疗,随访6个月,比较治疗前及治疗后6个月两组患者三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、空腹胰岛素（FINS）、空腹血糖（FBG）、卵泡刺激素（FSH）、黄体生成素（LH）及睾酮（T）的变化,并记录两组患者妊娠、流产等发生情况.结果 治疗后两组TC、LDL-C、FINS、FBG、FSH、LH、T均较治疗前明显下降,观察组TG较治疗前明显下降,差异有统计学意义（P＜0.05）；对照组治疗前后TG比较差异无统计学意义（P＞0.05）.观察组治疗后TG、FINS、FBG、LH明显低于同期对照组（1.0±0.2） mmol/L比（1.6±0.8）mmol/L、（15.2±6.3） mU/L比（18.9±6.2） mU/L、（4.5±1.1） mmol/L比（5.1±0.9）mmol/L、（6.3±3.0）U/L比（7.4±2.9） U/L],差异有统计学意义（P＜0.05）.治疗后观察组妊娠率高于对照组61.2％（49/80）比42.5％（34/80）],差异有统计学意义（x2=5.633,P＜0.05）；而流产率低于对照组6.1％（3/49）比17.6％（6/34）],但差异无统计学意义（x2=1.694,P＞0.05）.结论 达英-35联合二甲双胍治疗PCOS临床效果优于单用达英-35.

The clinical research of ethinylestradiol and cyproterone acetate combined with metformin in patients with polycystic ovary syndrome

Objective To explore the clinical efficacy of ethinylestradiol and cyproterone acetate （Diane-35） combined with mefformin in patients with polycystic ovary syndrome （PCOS）.Methods One hundred and sixty patients with PCOS were divided into control group and observation group by random digits table method with 80 cases each.Patients in the control group were given Diane-35 only,while patients in the observation group were given Diane-35 combined with metformin.The triglycerides （TG）,total cholesterol （TC）,low density lipoprotein cholesterol （LDL-C）,fasting insulin （FINS）,fasting blood glucose （FBG）,follicle-stimulating hormone （FSH）,luteinizing hormone （LH） and testosterone （T） of patients in the two groups were measured before treatment and after treatment 6 months,the rates of pregnancy and abortion were recorded.Results TC,LDL-C,FINS,FBG,FSH,LHt and T of both the 2 groups after treatment decreased obviously than before treatment,and TG in observation group decreased obviously than before treatment,there were statistical differences （P 〈 0.05）.There was no statistical difference in TG in control group between before treatment and after treatment （P 〉 0.05）.After treatment,TG,FINS,FBG,LH in observation group were lower than those in control group （1.0 ± 0.2） mmol/L vs.（1.6 ± 0.8） mmol/L,（15.2 ± 6.3） mU/L vs.（18.9 ± 6.2） mU/L,（4.5 ± 1.1） mmol/L vs.（5.1 ± 0.9） mmol/L,（6.3 ± 3.0） U/L vs.（7.4 ± 2.9） U/L],there were statistical differences （P 〈 0.05）.After treatment,the rate of pregnancy in observation group was higher than that in control group 61.2%（49/80） vs.42.5%（34/80）],there was statistical difference （x2 =5.633,P〈 0.05）.The rote of abortion in observation group was lower than that in control group 6.1%（3/49） vs.17.6%（6/34）],but there was no statistical difference （x2 =1.694,P 〉 0.05）.Conclusion The clinical effect of Diane-35 combined with metformin in patients with PCOS is better than Diane-35 only.