蒲地蓝消炎口服液联合思密达治疗复发性咽部溃疡患者的疗效及对免疫功能的影响

目的 分析蒲地蓝消炎口服液联合思密达治疗复发性咽部溃疡患者的疗效及对患者免疫功能的影响.方法 本研究病例选自于2014年8月至2015年8月接受诊治的复发性咽部溃疡患者80例,随机分为研究组与对照组,每组40例.研究组采用蒲地蓝消炎口服液联合思密达治疗,对照组仅采用思密达治疗.两组患者均以10 d为治疗疗程.对比分析两组患者治疗总有效率、溃疡愈合时间,治疗前与治疗10 d免疫功能T淋巴细胞亚群变化及不良反应发生情况.结果 研究组治疗总有效率高于对照组(90.00％比70.00％),差异有统计学意义(P＜0.05);研究组溃疡愈合时间为(8.59±2.13)d,显著快于对照组的(19.84±3.45)d,差异有统计学意义(P＜0.05);两组患者治疗后CD4+和CD4+/CD8+较治疗前增加,而CD8+较治疗前下降(P＜0.05);研究组患者治疗后CD4+(39.81±3.18)％]和CD4+/CD8+(1.76±0.39)高于对照组(34.28±2.6)％、(1.34±0.24)],而CD8+低于对照组(22.67±2.09)％比(25.62±2.45)％],差异有统计学意义(P＜0.05);两组用药10 d期间均未出现明显药物不良反应.结论 蒲地蓝消炎口服液联合思密达治疗复发性咽部溃疡患者疗效显著,且能够增强患者免疫功能,值得研究.

The curative effect of Pudilan antiphlogistic oral liquid combined with smecta in the treatment of recurrent pharyngeal ulcer and its effect on immune function of patients

Objective To analyze the curative effect of Pudilan antiphlogistic oral liquid combined with smecta in the treatment of recurrent pharyngeal ulcer and its effect on immune function of patients.Methods 80 patients with recurrent pharyngeal ulcer were selected from August 2014 to August 2015,and randomly divided into study group and control group,40 cases in each group.The study group was treated with Pudilan antiphlogistic oral liquid combined with smecta,while the control group was only treated with smecta.The patients in the two groups were treated for 10 d.The total effective rate,ulcer healing time,lymphocyte subsets changes before and 10 d after treatment,and adverse reactions were compared between the two groups.Results The total effective rate of the study group (90.00％) was higher than that of the control group (70.00％) (P＜0.05).The ulcer healing time of the study group (8.59±2.13)d] was significantly shorter than that of the control group (19.84±3.45)d] (P＜0.05).CD4+ and CD4+/CD8+ significantly increased after treatment in the two groups,while CD8+ decreased (P＜0.05);CD4+ and CD4+/CD8+ after treatment in the study group were higher than those in the control group (39.81±3.18)％ vs.(34.28±2.6)％,(1.76±0.39) vs.(1.34±0.24)],CD8+ was lower than that in the control group (22.67±2.09)％ vs.(25.62±2.45)％] (P＜0.05).There were no obvious adverse drug reactions in the two groups during the period of 10 d.Conclusion Pudilan antiphlogistic oral liquid combined with smecta in the treatment of recurrent pharyngeal ulcer has obvious curative effect,which can enhance the immune function of patients,worthy of study.