A tandem enzymatic hydrolysis of 3-acetylthio-2-methylpropionic methy ester |
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| Authors: | Dar-Fu Tai Ching-Chong Huang Hui-Yao Huang Ing-Lung Shih |
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| Affiliation: | (1) Biochemical Engineering Center, Da-Yen Institute of Technology, Chang-Hwa, Taiwan, R.O.C. |
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| Abstract: | Summary Enzymatic hydrolysis of racemic 3-acetylthio-2-methylpropionic methyl ester catalyzed by bovine pancreatic protease and Mucor javanicus lipase showed opposite enantioselecivity. A tandem hydrolysis of the ester catalyzed by these two enzymes gives enantiomerically enriched (S)-3-acetylthio-2-methylpropionic acid, a building block of captopril. |
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