胰岛素泵与胰岛素多次皮下注射治疗2型糖尿病的疗效对比

目的：对比观察胰岛素泵与传统胰岛素多次皮下注射治疗维吾尔族2型糖尿病的疗效。方法：80例维吾尔族2型糖尿病患者被随机分为两组：胰岛素泵持续皮下输注（CSII）组（40例），常规多次胰岛素皮下注射（MSII）组（40例），分别对两组治疗前、治疗后血糖、糖化血红蛋白水平，血糖达到强化治疗目标空腹血糖（FBG）〈7．0mmol／L，餐后2h血糖（2hBG）〈10．0mmol／L]的时间、每日胰岛素用量及低血糖发生情况进行对比。结果：两组治疗后FBG、2hBG、糖化血红蛋白（HbAlC）浓度均低于治疗前（P均〈0．05）。CSII组治疗后各时段血糖（FBG，2hBG）均明显低于MSII组（P〈0．01，〈0．05）。和MSII组比较，CSII组血糖达到强化治疗目标时间显著减少（12．9±3．3）d：（8．3±2．1）d]，胰岛素用量显著减少（46．9±5．1）U／d：（30．5±6．7）U／d]。P均〈0．001。结论：胰岛素泵强化治疗控制糖尿病患者血糖优于常规胰岛素治疗方法，值得推广。

Comparison of therapeutic efficacy between continuous subcutaneous insulin infusion with pump and multi subcutaneous insulin injection in patients with type 2 diabetes

Objective： To compared therapeutic efficacy between continuous subcutaneous insulin infusion with pump （CSII） and multi subcutaneous insulin injection （MSII） in Uygur patients with type 2 diabetes. Methods： Eighty Uygur patients with type 2 diabetes were averagely divided into two groups： CSII group and MSII group. The treat targets of blood glucose were fasting blood glucose （FBG） ≤7.0 mmol/ L, 2 h postprandial blood glucose （2 h BG） ≤10.0 mmol/L. Results： After treatment, the value of FBG, 2hBG, glycosylated hemoglobin （HbAIC） signifi- cantly decreased in both groups （P〈0.05 all） . Compared with MSII group, the values of blood glucose （FBG, 2hBG） significantly decreased after treatment in CSII group （P〈0.01, P〈0.05）3 the average duration （12. 9± 3.3） d vs. （8. 3±2. 1） d] of treatment and insulin dose （46.9±5.1） U/d vs. （30.5±6.7） U/d] reached to treat targets of blood glucose significantly decreased in CSII group （P〈0. 001 all）. Conclusion： Continuous subcutaneous insulin infusion with pump is superior to multi subcutaneous insulin injection in patients with type 2 diabetic.