| 窦房结细胞自律性与超极化激活起搏电流关系的研究进展 |
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| 引用本文： | 汪艳丽.窦房结细胞自律性与超极化激活起搏电流关系的研究进展[J].医学综述,2011,17(12):1778-1780. |
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| 作者姓名： | 汪艳丽 |
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| 作者单位： | 中国中医科学院广安门医院心内科,北京,100053 |
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| 基金项目： | 国家自然科学基金，北京市自然科学基金 |
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| 摘 要： | 窦房结是正常心脏活动的起搏点,在心脏传导系统中自律性最高,窦房结细胞的自动除极是其自律性产生的基础,多种离子通道及相应电流参与窦房结细胞自律性活动,其中超极化激活环核苷酸门控通道(HCN)及其电流(If)在窦房结细胞自律性产生过程中起着重要作用,HCN通道共有HCN1~4四个亚型,在心脏窦房结细胞中HCN4是主要的亚型,负责形成If,HCN4及相关If对窦房结自律性有着重要的影响。
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| 关 键 词： | 窦房结细胞 离子通道 超极化激活起搏电流 |
Research Progress in Relation between Automaticity of Sinoatrial Node Cells and Funny Current |
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| WANG Yan-li.Research Progress in Relation between Automaticity of Sinoatrial Node Cells and Funny Current[J].Medical Recapitulate,2011,17(12):1778-1780. |
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| Authors: | WANG Yan-li |
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| Affiliation: | WANG Yan-li,LIU Ru-xiu.(Department of Cardiology,Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China) |
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| Abstract: | Sinoatrial node(SAN)is the primary cardiac pacemaker with the highest automaticity in the conducting system of heart.The automatic depolarization of sinoatrial node cells is the basis of its automaticity.Many different membrane ionic channels and their currents coordinately take part in the automatic activity,in which the hyper-polarization-activated cyclic nucleotide-gated cation channel(HCN)and its funny current(If)play an important role.There are four isoforms in HCN family,and HCN4 is the most important... |
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| Keywords: | Sinoatrial node cell Ionic channel Funny current |
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