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| MPTP/MPP~+诱导的帕金森病实验模型的研究进展 | |
| 引用本文： | 解洪荣,张玉花,李雪松,王立崚.MPTP/MPP~+诱导的帕金森病实验模型的研究进展[J].医学综述,2011,17(5):669-672. |
| 作者姓名： | 解洪荣 张玉花 李雪松 王立崚 |
| 作者单位： | 1. 大庆油田总医院神经内科,黑龙江,大庆,163001;吉林大学第一医院神经内科,长春,130021 2. 大庆油田总医院CT室,黑龙江,大庆,163001 3. 大庆油田总医院神经内科,黑龙江,大庆,163001 |
| 摘 要： | 建立一个稳定可靠的实验模型对研究帕金森病(PD)的发病和治疗是尤其必要的。自从发现1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)能在人类诱发PD以来,人们对其神经毒性作了大量研究。MPTP及其有效成分1-甲基-4-苯基吡啶离子(MPP+)对中脑黑质多巴胺能神经元有选择性的破坏作用,从而发挥其诱导PD的毒性作用。在过去的几十年里对MPTP/MPP+诱导的PD实验模型的研究取得了显著的进展,目前MPTP/MPP+诱导的PD实验模型已广泛地用于PD研究。 |
| 关 键 词： | 1-甲基-4-苯基-1 2 3 6-四氢吡啶 1-甲基-4-苯基吡啶离子 帕金森病 实验模型 |
MPTP/MPP+-induced Experimental Model of Parkinson Disease |
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| XIE Hong-rong,ZHANG Yu-hua,LI Xue-song,WANG Li-ling.MPTP/MPP+-induced Experimental Model of Parkinson Disease[J].Medical Recapitulate,2011,17(5):669-672. | |
| Authors: | XIE Hong-rong ZHANG Yu-hua LI Xue-song WANG Li-ling |
| Affiliation: | XIE Hong-rong1,2,ZHANG Yu-hua3,LI Xue-song1,WANG Li-ling1,HU Lin-sen2.(1.Department of Neurology,Daqing Oilfield General Hospital,Daqing 163001,China,2.Department of Neurology,the First Hospital,Jilin University,Changchun 130021,3.Department of Computerized Tomography,China) |
| Abstract: | The development of a stable and reliable experimental model is particularly necessary for the study of the pathogenesis of Parkinson disease(PD) and the development of therapeutic strategies.As 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) has been shown to induce PD in humans,the neurotoxicity of MPTP has been extensively studied.It is found that MPTP and its active neurotoxic metabolite 1-methyl-4-phenyl-pyridinium(MPP+) can selectively damage substantia nigra dopaminergic neurons,inducing the neurot... |
| Keywords: | 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine 1-methyl-4-phenylpyridinium ion Parkinson disease Experimental model |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
