黄芪注射液对小儿病毒性心肌炎细胞免疫功能及心肌酶谱的影响

目的：探讨黄芪注射液对小儿病毒性心肌炎细胞免疫功能及心肌酶谱的影响。方法将86例符合入选标准的病毒性心肌炎患儿采用随机数字表法分为2组，对照组41例给予1,6-二磷酸果糖治疗，观察组45例在对照组基础上加用黄芪注射液，均治疗3周。比较2组治疗前后心肌酶谱及免疫功能的变化，评价临床疗效。结果观察组总有效率为95.56%(43/45)，对照组为80.49%(33/43)，2组比较差异有统计学意义(χ2＝4.740，P＜0.05)。治疗后，观察组 CD3+(64.9±8.8)%比(52.7±8.2)%，t＝6.633]、CD4+(41.7±6.5)%比(37.3±7.2)%，t＝2.978]、CD8+(28.9±4.2)%比(26.4±4.3)%，t＝2.726]水平高于对照组(P＜0.05)。观察组肌酸激酶(129.7±29.8)U/L 比(167.7±34.5)U/L，t＝-5.479]、肌酸激酶同工酶(12.7±4.2)U/L比(18.9±6.2)U/L，t＝-5.472]、乳酸脱氢酶(165.3±38.4)U/L比(197.2±46.3)U/L，t＝-3.489]、肌钙蛋白Ⅰ(0.129±0.012)μg/L 比(0.204±0.071)μg/L，t＝-6.981]水平均低于对照组(P＜0.05)。结论黄芪注射液可明显提高病毒性心肌炎患儿细胞免疫功能，降低心肌酶谱，提高临床疗效。

The effect of Huangqi injectionon theimmune function and myocardial enzymes of the children with viral myocarditis

ObjectiveTo investigate the effect of Huangqiinjection on the immune function of cardiomyocytes and myocardial enzymes of the children with viral myocarditis.MethodsA total of 86 patients who met the inclusion criteria of viral myocarditis were randomized into two groups. Fourty-onepatients in the control group took 1, 6 Fructose Diphosphate (FDP), and 86 patients of the treatment group tookHuangqi injection based on the intervention of control group. Both groups were treated for three weeks. The main outcomes were myocardial enzymes and immune function of cardiomyocytes.ResultsTotal effective rate of treatment group was significantly higher than the control group (95.56%vs. 80.49%;χ2=4.740,P<0.05). After treatment, the levels of CD3+ (64.9% ± 8.8%vs. 52.7% ± 8.2%,t=6.633), CD4+ (41.7% ± 6.5%vs.37.3% ± 7.2%,t=2.978), CD8+ ( 28.9% ± 4.2%vs.26.4% ± 4.3%,t=2.726) of treatment group were siginificantly higher than the control group (P<0.05). The CK (129.7 ± 29.8 U/Lvs. 167.7 ± 34.5 U/L,t=-5.479), CK-MB (12.7 ± 4.2 U/L vs.18.9 ± 6.2 U/L,t=-5.472), LDH (165.3± 38.4 U/Lvs.197.2 ± 46.3 U/L,t=-3.489), cTnⅠ(0.129 ± 0.012μg/Lvs. 0.204 ± 0.071μg/L,t=-6.981) of treatment group were significantly lower than the control group (P<0.05). Conclusion Huangqiinjection can significantly improve the clinical efficative rates, the immune function of cardiomyocytes and reduce the myocardial enzymes of children with viral myocarditis.