吸入麻醉药作用机制的5埃理论

在过去的20多年中，对吸入麻醉药作用机制的合理解释大量增多，同时也提出了更多目前还不能回答的问题。Eger等提出了吸入麻醉药产生对伤害性刺激无体动反应的作用靶位可能是两个相距5埃的位点的假设，简称5埃理论。现就相关问题作一综述。

A 5-angstrom theory in the mechanisms of volatile anesthetic agents

Plausible explanations for anesthetic actions increased enormously, and some more unanswerable questions rose in the past two decades. Eger El II, et al. suggest that volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart, i.e. A 5-angstrom theory. The hypothesis is based on the finding that fluorinated alkanes having active anesthetic sites at each end of the molecule produce anesthesia as long as the total number of carbon atoms in their structure does not exceed five, and on the sustaining of the 5-A separation by the rigidity produced by fluorination.