铁必复颗粒治疗缺铁感音神经性聋患者的疗效分析

目的 探讨铁必复颗粒治疗有缺铁的感音神经性耳聋患者的临床疗效。 方法 收集感音神经性耳聋患者1 214例,检查血清铁蛋白,筛查出存在缺铁的患者217例,其中单侧耳聋患者54例,双侧163例,以听力较好耳为观察对象,完全随机分为两组,铁必复颗粒组109耳,西药对照组108耳,铁必复颗粒组接受铁必复颗粒冲服,西药对照组口服常规剂量新B1、敏使朗、弥可保等,两组患者均连续用药2个月以上。分别在用药前1~3 d,治疗1、2个月时测平均电测听阈值和血清铁蛋白,观察听力改变与血清铁蛋白变化是否相关。 结果 治疗1个月后铁必复颗粒组有78耳(71.6%)血清铁蛋白恢复正常值,2个月后共有97耳(89.0%)血清铁蛋白恢复正常值,对照组分别为11耳(10.2%)和15耳(13.9%),秩和检验两组有效率差异有统计学意义(P<0.001)。听力测试结果显示治疗2个月后铁必复颗粒组显效9耳,有效48耳,总有效率为52.3%;西药对照组108耳,显效2耳,有效22耳,总有效率为22.2%。铁必复颗粒组有效率高于西药对照组,经秩和检验两组总有效率差异有统计学意义(P<0.05)。铁必复颗粒组听阈提高与血清铁蛋白的上升呈正相关,西药对照组无相关性。 结论 部分感音神经性耳聋可能与缺铁有关,铁必复颗粒能有效改善人体内缺铁状况,有效改善缺铁并感音神经性耳聋患者的听力情况。

Clinical efficacy of Tiebifu Granule in the treatment of deafness with iron deficiency

Objective To explore the clinical efficacy of Tiebifu Granule in the treatment of deafness with iron deficiency.Methods A total of 217 cases with iron deficiency including 163 cases of unilateral deaf and 54 cases of bilateral deaf were screened from 1 214 cases of sensorineural deafness and randomly divided into 2 groups:Tiebifu Granule group (n =109,taking Tiebifu Granule for 2 months) and control group (n =108,taking vitamin B1,mesylate,or methycobal for 2 months).The average threshold and serum ferritin were observed 1-3 days before medication,and 1 month and 2 months after taking medicine.Results One month after taking medicine,the serum ferritin level returned normal in 71.6％ and 10.2％ cases in the Tiebifu Granule group and control group,while the rate increased to 89％ and 13.9％ two months after taking medicine,showing significant difference between the two groups (P ＜ 0.001).The total effective rate of Tiebifu Granule group and control group was 52.3％ and 22.2％,respectively,with significant difference between the two groups (P ＜ 0.001).Relevance between hearing improvement and serum ferritin increase was found in the Tiebifu Granule Group,but not in the control group.Conclusion Tiebifu Granule can effectively treat sensorineural deafness with iron deficiency.