脑血疏口服液与大骨瓣减压硬膜扩大减张缝合术治疗大面积脑梗死的疗效及对血清NSE和hs-CRP水平的影响

目的:探讨脑血疏口服液配合大骨瓣减压硬膜扩大减张缝合术对大面积脑梗死患者的临床疗效及对血清超敏C反应蛋白(hs-CRP)及神经元特异性烯醇化酶(NSE)水平的影响。方法:选取2013年1月~2015年1月我院收治的大面积脑梗死患者87例,采用随机单盲取法分为试验组44例,对照组43例。两组患者均给予标准大骨瓣减压硬膜扩张缝合术治疗,对照组术后给予常规及对症治疗,试验组在对照组基础上给予脑血舒口服液治疗。观察两组患者治疗前后hs-CRP、NSE水平变化,同时进行日常生活活动能力量表(ADL)评分、神经功能缺损量表(NIHSS)评分及生活质量指数(BI)测定,并评定和比较治疗效果。结果:治疗1疗程后,试验组总有效率为97.73%,显著高于对照组81.40%(P0.05)。两组血清hs-CRP、NSE水平ADL、NIHSS评分均显著低于治疗前(P0.05),BI指数明显高于治疗前,且试验组血清hs-CRP、NSE水平ADL、NIHSS评分明显低于对照组(P0.05),BI指数明显高于对照组(P0.05)。两组治疗期间均未见严重不良反应。结论:脑血舒口服液配合大骨瓣减压硬膜扩大减张缝合术治疗大面积脑梗死患者可有效提高临床疗效,且安全性高,可能与其降低血清NSE、hs-CRP水平有关。

Effect of Naoxueshu Oral Liquid Combined with Large Bone Flap Decompression on Treatment of Large Area Cerebral Infarction and NSE and hs-CRP in Patients

ABSTRACT Objective: To investigate the effect of Naoxueshu oral liquid combined with large bone flap decompression dural su- ture surgery on the patients with large area of cerebral infarction and the serum high-sensitivity C reactive protein (hs-CRP) and neuron specific enolase (NSE) levels. Methods: 87 patients with large area of cerebral infarction admitted in our hospital from January 2013 to January 2015 were randomly divided into the trial group and the control group. Both groups of patients were given standard big bone flap decompression of dural suture expansion treatment, while the control group was given routine and symptomatic treatment, the experimen- tal group was given naoxueshu oral liquid treatment. Then the serum levels of hs-CRP and NSE, and activities of daily living the ability to scale (ADL) score, neural function defect scale (NIHSS) score and quality of life index (BI) were measured and compared between two groups before and after treatment. Results: After treatment, the total effective rate of experimental group was significantly higher than that of the control group (P<0.05). The serum hs-CRP, NSE levels of ADL and NIHSS scores in both groups were significantly lower than those before treatment (P<0.05); BI index in the two groups were significantly higher than that before treatment, and the serum hs-CRP, NSE levels of ADL and NIHSS in experimental group were significantly lower than those of the control group (P<0.05); BI index in the experimental group was significantly higher than that of the control group (P<0.05). No serious adverse reactions was observed in both groups. Conclusion: Naoxueshu oral liquid combined with large bone flap decompression dural suture surgery was effective to improve the clinical efficacy and the safety of in the treatment of massive cerebral infarction, which might be related to reduce the serum levels of NSE and hs-CRP.