脂肪干细胞在泌尿系统疾病中的研究进展

脂肪干细胞(adipose-derived stem cells,ADSCs)是一类从脂肪分离出来的具有自我更新及多向分化潜能的成体干细胞,ADSCs具有高度的可塑性,可分化成多种类型的细胞。与其他干细胞相比,ADSCs具有来源充足,取材方便,供体易接受等独特优势,已成为基础医学及临床治疗的研究热点。ADSCs诱导分化和移植可有效治疗多种组织损伤性疾病,改善或修复器官功能,近年来ADSCs作为细胞疗法及组织工程的新型种子细胞在泌尿系统疾病治疗中取得了重大进展。本文重点讨论ADSCs的生物学特性及其在泌尿系统疾病中的应用前景。

The Research Progress of Adipose-derived Stem Cells in Urinary Tract Diseases

ABSTRACT: Adipose-derived stem cells (ADSCs) is a kind of adult stem cells separated from the fat ,which have the capacity of self-renewal and multi-differentiation. ADSCs have a high degree of plasticity, and could be induced to differentiate into a variety of cells. Compared with other stem cells, ADSCs have become a hot research topic in basic medical and clinical treatment due to the unique advantages of sufficient source, convenient and easy to accept the donor. The differentiation and transplantation of ADSCs can effectively treat many tissue injury diseases, improve or restore organ function. As perfector seed cells, In recent years, ADSCs for cell therapy and tissue engineering of the new seed cells have made great progress in the treatment of urinary system disease. This paper focuses on the prospect of the biological characteristics of ADSCs and its application in urinary tract diseases.