The effect of partially stabilized zirconia on the biological properties of HA/HDPE composites in vitro |
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Authors: | A Yari Sadi M A Shokrgozar S Sh Homaeigohar M Hosseinalipour A Khavandi J Javadpour |
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Affiliation: | (1) National Cell Bank of Iran, Pasteur Institute of Iran, Iran;(2) Department of materials science and engineering, Iran University of Science and Technology (IUST), Tehran, Iran |
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Abstract: | The effect of partially stabilized zirconia (PSZ) on the biological properties of the hyroxyapatite - high density polyethylene
(HA/HDPE) composites was studied by investigating the simultaneous effect of hydroxyapatite and PSZ volume fractions on the
in vitro response of human osteoblast cells. The biocompatibility of composite samples with different volume fraction of HA and PSZ
powders was assessed by proliferation, alkaline phosphatase (ALP) and cell attachment assays on the osteoblast cell line (G-292)
in different time periods. The effect of composites on the behavior of G-292 cells was compared with those of HDPE and TPS
(Tissue Culture Poly Styrene as negative control) samples. Results showed a higher proliferation rate of G-292 cells in the
presence of composite samples as compared to the HDPE sample after 7 and 14 days of incubation period. ALP production rate
in all composite samples was higher than HDPE and TPS samples. The number of adhered cells on the composite samples was higher
than the number adhered on the HDPE and TPS samples after the above mentioned incubation periods. These findings indicates
that the addition of PSZ does not have any adverse affect on the biocompatibility of HA/HDPE composites. In fact in some experiments
PSZ added HA/HDPE composites performed better in proliferation, differentiation and attachment of osteoblastic cells. |
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