围手术期预防性使用抗菌药物合理性调查

目的:调查围手术期预防性使用抗菌药物的合理性,以提高合理用药水平。方法:对我院2006年3月948例住院手术患者围手术期抗菌药物预防性使用进行回顾性调查分析。结果:948例患者在抗菌药物1841次的预防性使用中,合理1039次(56.44%);基本合理189次(10.27%);不合理613次(33.29%)。不合理用药的主要表现形式为:用药时间过长,给药时间不当,剂量过大,选药不正确,非适宜指证,给药次数过少等。结论:围手术期预防性使用抗菌药物过程中存在某些不合理用药的情况。为此,应加强贯彻实施《抗菌药物临床应用指导原则》,以避免抗菌药物的不适宜应用。

Investigation of rationality of prophylactic antibacterial use in perioperative period

Objective: To investigate the rationality of prophylactic antibacterial use in the perioperative period in order to elevate the levels of rational drug use. Methods: Nine hundred and forth-eight inpatients receiving surgical procedure were investigated and analysed retrospectively for prophylactic antibacterial use in March, 2006. Results: Of the 1 841 times of prophylactic antibacterial use in 948 cases, 1 039 (56.44%) were rational,189 (10.27%) basically rational, and 613 (33.29%) irrational. The patterns of irrational drug use were manifested in the following forms: overlong duration of administration, inappropriate timing of administration, overdose, incorrect choice of drugs, inappropriate indication, less frequency of administration, and so on. Conclusion: There were some patterns of irrational prescribing in the prophylactic antibacterial use in the perioperative period; therefore, it is necessary to carry out "Guidelines on Clinical Use of Antimicrobials" in order to avoid the inappropriate use of antibacterials.