Paraoxonase activity in type 2 diabetes mellitus patients with and without complications

Objective:Type 2 diabetes mellitus (DM) is a disease of metabolic dysregulation.Current study was undertaken to know the relation between fasting lipid profile and paraoxonase 1 (PON1) activity in type 2 diabetic patients with and without complications.Methods:The study group consisted of a total of 155 subjects which included non-diabetic healthy control subjects (n = 50) and diabetic patients with complications (group Ⅰ,n = 66) and without complications (group Ⅱ,n=39).PON1 activity was measured all the subjects based on spectrophotometric methods,and fasting lipid profile and fasting plasma glucose (FPG) levels were determined in clinical chemistry analyzer Hitachi 912.Results:FPG (P<0.001) and TAG (P<0.001) significantly increased,and HDL-C (P<0.001) and PON1 (P<0.001) were significantly decreased in group I patients when compared to normal controls.In group Ⅱ patients FPG (P<0.001),TAG (P <0.001) and TC (P<0.05) significantly increased and HDL-C (P<0.05) was significantly decreased when compared to normal controls.On Pearson correlation,HDL-C was positively correlated with PPN1 in group I patients (r= 0.317,P<0.01 ).Conclusion:type 2 DM patients with complications have significantly decreased HDL-C levels and PON1 activity possibly indicating its decreased biochemical role in these patients.