陡脉冲不可逆性电击穿恶性肿瘤细胞的机理

电场的基本特性是对处于场中的物质有力的作用.在陡脉冲电场作用下,细胞膜内外表面有很强的电场分布,同时由于细胞膜的介电常数与细胞外液、细胞质的不同,从电磁场理论出发,必然有作用于细胞膜表面的电场应力.仿真计算结果表明,外加电场的作用使得细胞膜受到来自细胞外液与细胞质两个方向的压力,作用在恶性肿瘤细胞膜上的电场应力的数量级比正常细胞大1个数量级.因此,在陡脉冲电场的作用下,恶性肿瘤细胞比正常细胞具有更大的敏感性,这种电场应力的作用势必对恶性肿瘤细胞膜造成巨大的损伤,使得细胞的生存环境和遗传物质受到严重破坏,并导致细胞发生不可逆性电击穿而死亡.

Irreversible Electrical Breakdown of Malignant Tumor Cell Under Steep Pulsed Electric Fields

The basic characteristic of electric field is that the substance in the field is in operation by the stress. Under steep pulsed electric fields, there is strong distribution of electric fields on the inside and outside surfaces of cell membrane. In virtue of the difference of the permittivity among membrane, cytoplasm and extracellular medium, there must be the electric field stress on the surface of the membrane. The calculation results showe that cell membrane is stressed from two directions of cytoplasm and extracellular medium under external electric fields. The stress on tumor cell membrane is greatly larger than normal cell membrane, so the tumor cell is more sensitive than normal cell. Tumor cell membrane certainly will be destroyed by electric field stress, then its survival environment and germ plasm will be injured and accordingly the cell will be damaged.