液基薄层细胞检测诊断宫颈病变的临床研究

目的探讨液基薄层细胞检测（TCT）在筛查和诊断宫颈疾病方面的价值。方法对330例患者同时行巴氏涂片法与TCT法宫颈细胞学检测，对81例细胞学检测阳性（ASCUS／ASGUS及以上）者进一步行阴道镜下宫颈活组织检查，观察比较其检测阳性率及准确度。结果TCT法对异常细胞的阳性检出率明显高于巴氏涂片法（23．94％vs 16．06％，P〈0．05），对重度细胞病变（LSIL及以上）的检出率提高42．92％。以阴道镜下宫颈活检为金标准，TCT法的阳性符合率显著高于巴氏涂片法（67．09％vs 45．28％，P〈0．05）。结论与巴氏涂片法相比，应用TCT法筛查宫颈病变具有更高的敏感性TCT法联合阴道镜下活检能提高宫颈癌前病变的诊断准确率。

Fluid-based ThinPrep cytology teat in the diagnosis of cervical diseases

Objective To explore the value of ThinPrep cytology test (TCT) in the screening and diagnosis of cervical diseases. Methods 330 patients were detected by Pap smear and fluid-based TCT. Those with positive cytological results (ASCUS or above) received colposcopic biopsies. The findings of biopsy were compared with that of the cytological test. Results The rate of abnormal epithelial cells identified by TCT was significantly higher than that of Pap smear (23.94% vs. 16.06%, P<.0.05). And the rate of severe cellular abnormity detected by TCT increased by 42.92%. With colposcopy-guided biopsies as the gold standard, the positive coincidence rate of TCT was significantly higher than that of Pap smear (67.09% vs. 45. 28%, P< 0.05). Conclusions ThinPrep cytology test is more sensitive than pap smear in screening cervical diseases, and TCT combined with colposcopy-guided biopsies may increase the accuracy of diagnosis.