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| 2-氨基-4,6-二甲氧基嘧啶的合成研究 | |
| 引用本文： | 石桂珍,车光贤,王兴涌.2-氨基-4,6-二甲氧基嘧啶的合成研究[J].淮阴工学院学报,2007,16(5):70-72. |
| 作者姓名： | 石桂珍 车光贤 王兴涌 |
| 作者单位： | 1. 潍坊教育学院,化工系,山东,青州,262500 2. 二炮士官学校,山东,青州,262500 3. 中国矿业大学,化工学院,江苏,徐州,221008 |
| 摘 要： | 以丙二酸二乙酯和硝酸胍为原料,在醇钠的碱性体系中发生亲核加成-消去反应(环化)首先合成了2-氨基-4,6-二羟基嘧啶;然后经氯化和烷氧基化反应合成了2-氨基-4,6-二甲氧基嘧啶。采用单因素法探索了反应时间、pH值和催化剂等因素对产物收率的影响,优化了反应条件,达到节省能源、降低成本和简化操作的效果,有利于大规模的工业化生产。 |
| 关 键 词： | 2-氨基嘧啶 合成 加成-消去反应 |
| 文章编号： | 1009-7961(2007)05-0070-003 |
| 修稿时间： | 2007年6月30日 |
Study on the Synthesis of 2-Amino-4,6-Dimethoxypyrimidine |
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| SHI Gui-Zhen,CHE Guang-Xian,WANG Xing-Yong.Study on the Synthesis of 2-Amino-4,6-Dimethoxypyrimidine[J].Journal of Huaiyin Institute of Technology,2007,16(5):70-72. | |
| Authors: | SHI Gui-Zhen CHE Guang-Xian WANG Xing-Yong |
| Abstract: | The intermediate 2-amino-4,6-dihydroxypyrimidine was first synthesized with diethyl malonate and guanidine nitrate as raw materials by reaction of nucleophilic addition-elimination reaction(cyclization) in sodium ethylate.Then,2-amino-4,6-dimethoxypyrimidine was synthesized by chlorination reaction and alkoxylation reaction.In order to obtain maximal yield of the products,the effect of reaction time,pH value and catalyst was studied by single factor experiment.The experimental conditions were optimized,and the optimized method is featured of energy saving,lower cost,easier operation.It is conducive to large-scale industrialization production. |
| Keywords: | 2-aminopyrimidine synthesis addition-elimination reaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
