妊娠高血压综合征患者血浆von Willebrand因子与一氧化氮水平的变化

目的 :探讨妊娠高血压综合征 (妊高征 )患者血浆vonWillebrand因子 (vWF)和一氧化氮 (NO)水平的变化。方法 :分别采用酶联免疫吸附试验 (ELISA法 )和Griess法测定 36例妊高征患者及 18例正常妊娠妇女血浆vWF和NO水平。结果 :中、重度妊高征患者血浆vWF高于正常妊娠妇女 ;妊高征患者血浆NO水平低于正常妊娠妇女 ;vWF水平越高或NO水平越低 ,妊高征病情越重。中、重度妊高征患者血浆vWF与NO呈明显负相关 (r =- 0 .5 48,P<0 .0 1)。结论 :vWF和NO可作为判断妊高征病情程度的指标 ;vWF和NO在中重度妊高征患者的发病中起相互拮抗作用

Changes in plasma von Willebrand factor and nitric oxide levels in patients with pregnancy induced hypertension

Objective To study the changes and clinical significance of plasma von Willebrand factor (vWF) and nitric oxide (NO) levels in patients with pregnancy induced hypertension (PIH). Methods Plasma vWF and NO were detected by ELISA and Griess assay respectively in 36 patients with PIH and 18 healthy pregnant women. Results The levels of plasma vWF in patients with moderate and severe PIH increased significantly than those in healthy pregnancy. The levels of plasma NO in patients with PIH were significantly lower than those in healthy pregnancy. The higher the vWF levels or the lower the NO levels, the more severe in PIH. There was a negative correlation between the plasma vWF and NO levels. Conclusion The results suggest that plasma vWF and NO concentration can be used as indicators in the judgement of the severity of PIH.