微波辐射对大鼠造血组织形态和功能的影响研究

目的探讨微波辐射对大鼠造血组织形态及功能的影响。方法雄性Wistar大鼠144只,随机均分为4组:假辐射组(不接受辐射),2.5、5和10mW/cm2辐射组(分别接受2.55、、10mW/cm2的微波辐射,6min/次,每周5次,持续辐射30d)。分别在最后1次辐射结束后的6h及7、14、30、601、80d取6只大鼠,取下腔静脉血检测外周血白细胞、红细胞、血小板数及血红蛋白浓度。另取大鼠处死后取胸骨,经光镜和电镜观察骨髓组织学和超微结构改变。结果 5mW/cm2微波长期辐射结束后6h,大鼠外周血白细胞、中性粒细胞及红细胞数均较假辐射组有不同程度的下降,辐射后60d外周血红细胞、血小板数与假辐射组比较显著增加(P<0.05)。5、10mW/cm2组辐射后180d大鼠外周血白细胞、淋巴细胞及血小板数显著下降(P<0.01)。光镜下可见,骨髓造血细胞在辐射后14d变化并不明显,辐射后30d骨髓间质可见明显充血、水肿,辐射后180d可见造血细胞减少,脂肪细胞明显增多,并呈现一定的量效关系。5mW/cm2微波辐射后7d,电镜下可见骨髓中各系造血细胞呈凋亡和坏死改变。结论 5～10mW/cm2微波长期(30～180d)辐射可导致大鼠造血系统形态和功能改变,且与辐射剂量有关。

Effects of microwave radiation on morphology and function of hematopoietic system of rats

Objective To explore the effects of microwave radiation on the morphology and function of hematopoietic system in rats.Methods One hundred and forty-four male Wistar rats randomly divided into 4 groups(36 each) were exposed to microwave radiation at the average power density of 0,2.5,5 and 10 mW/cm2 respectively(0 mW/cm2 as sham group),with one exposure of 6 minutes,5 times per week,up to a total of 30 days.Six rats of each group were respectively sacrificed at 6 hours and 7,14,30,60 and 180 days post radia...