| 卷曲螺旋蛋白在胃癌发生发展中的研究进展 |
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| 引用本文： | 王启吉,袁学敏.卷曲螺旋蛋白在胃癌发生发展中的研究进展[J].世界华人消化杂志,2022(2). |
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| 作者姓名： | 王启吉 袁学敏 |
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| 作者单位： | 山东第一医科大学（山东省医学科学院）研究生部;临沂市人民医院消化内科 |
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| 摘 要： | 卷曲螺旋蛋白(coiled-coil domain containing protein,CCDC)是一类由两个及以上的卷曲螺旋结构域组成的同寡聚体或寡聚体序列蛋白.约40个卷曲螺旋蛋白家族基因与疾病相关,在肿瘤的发病过程中,卷曲螺旋蛋白基因既可以作为促癌基因也可作为抑癌基因,调控肿瘤的增殖、转移、血管生成和凋亡,与肿瘤的发生发展有着密切的关系.本文综述了CCDC家族相关蛋白在胃癌中的最新研究进展,探讨了其在胃癌发生发展中的作用与功能.
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| 关 键 词： | 卷曲螺旋蛋白 胃癌 分子机制 靶向治疗 |
Role of coiled-coil domain containing proteins in development of gastric cancer |
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| Qi-Ji Wang,Xue-Min Yuan.Role of coiled-coil domain containing proteins in development of gastric cancer[J].World Chinese Journal of Digestology,2022(2). |
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| Authors: | Qi-Ji Wang Xue-Min Yuan |
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| Affiliation: | (Graduate School,Shandong First Medical University and Shandong Academy of Medical Science,Jinan 250000,Shandong Province,China;Department of Gastroenterology,Linyi People’s Hospital,Linyi 276000,Shandong Province,China) |
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| Abstract: | Coiled-coil domain containing proteins(CCDCs)are a class of oligomeric proteins consisting of two or more coiled-coil domains.About 40 coiled coil family genes are associated with disease,and they can act as both pro-oncogenes and anti-oncogenes in the pathogenesis of tumors,regulating tumor proliferation,metastasis,angiogenesis,and apoptosis.Therefore,they are closely related to tumor development.This paper reviews the recent progress in the understanding of the role of CCDCs in gastric cancer,and explores their different roles and functions in the development of this malignancy. |
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| Keywords: | CCDC Gastric cancer Molecular mechanism Targeted therapy |
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