磁共振成像水脂分离技术在多发性骨髓瘤患者中的应用研究

目的:探讨磁共振成像水脂分离(Dixon)技术在多发性骨髓瘤患者中应用的临床意义.方法:将2019年4月至2021年4月于青岛大学附属医院行Dixon技术检查的初诊多发性骨髓瘤患者共41例纳入本研究.将患者按照Dixon表现是否正常分为观察组和对照组,比较两组患者临床资料、脂肪分数(FF)值的差异,比较FF与临床资料、...

Application of MRI Water-Fat Separation Technology in Patients with Multiple Myeloma

Objective:To explore the clinical significance of magnetic resonance imaging water-fat separation(Dixon)technique in patients with multiple myeloma.Methods:A total of 41 newly diagnosed patients with multiple myeloma who underwent Dixon in The Affiliated Hospital of Qingdao University from April 2019 to April 2021 were included in this study.Patients were divided into observation group and control group according to whether Dixon performance was normal or not.The differences of clinical data and fat fraction(FF) between the two groups were compared.The correlation between FF and clinical data,disease stages and differences before and after treatment were also compared.The receiver operator characteristic curve of patients was drawn to analyze the diagnostic value of FF combined with serum alkaline phosphatase for bone destruction in patients with multiple myeloma.Results:Among the 41 patients,there were 12 cases in the control group and 29 cases in the observation group.There was no significant difference in age and sex between the two groups.In the observation group,β;-microglobulin concentration and M protein were significantly higher than those in the control group,while serum alkaline phosphatase and FF were lower(P<0.05).In all 41 patients included in the study,there was a significant negative correlation between FF value and β;-microglobulin concentration(r=-0.57),and a significant positive correlation between FF value and serum alkaline phosphatase(r=0.31).After treatment,FF value increased,while myeloma cell percentage,β;-microglobulin concentration and M protein decreased in 11 patients who completed 4 cycles of chemotherapy,and the differences before and after treatment were statistically significant(P<0.05).The value of serum alkaline phosphatase combined with FF value in predicting bone destruction is higher than that of FF value or serum alkaline phosphatase alone.Conclusion:Dixon’s different imaging manifestations can reflect the severity of the disease.FF value is correlated with clinical examination results and R-ISS staging,and there is a significant difference before and after treatment.Serum alkaline phosphatase combined with FF value is better than two indicators alone in predicting bone destruction.