氟达拉滨诱导慢淋/幼淋细胞混合型白血病幼淋变达缓解(附1例报告及文献复习)

目的提高对慢淋/幼淋细胞混合型白血病及其幼淋变的认识,探索氟达拉滨的疗效。方法报道1例慢淋/幼淋细胞混合型白血病发生的幼淋变及其治疗过程和氟达拉滨的应用,并进行文献复习。结果和结论（1）幼淋巴细胞性白血病是一类少见的恶性淋巴增殖性疾病,其中一部分由慢淋/幼淋细胞混合型白血病转变而来,形态学与原发幼淋巴细胞性白血病类似;（2）FMC7与SmIg双阳性及6号染色体异常可能与幼淋变病例的临床和血液学特征密切相关;（3）氟达拉滨可诱导慢淋/幼淋细胞混合型白血病幼淋变达完全缓解。

Complete Remission in CLL/PL with Prolymphocytic Transformation After Fludarabine Therapy:One Case Report and Literature Review

Objective To call attention to CLL/PL with prolymphocytic transformation and explore the effect of fuldarabine on it. Methods The characteristics of CLL/PL with prolymphocytic transformation and the therapy, especially with fludarabine, was discussed and related literature was reviewed. Results Double positive expression of FMC7 and SmIg and abnormality of chromosomal 6 perhaps was close relevant to prolymphocytic transformation in clinical and hematology features. Con- clusion Prolymphocytic leukemia is one type of rare malignant lmpholiferative disorders, part of which is transformed from chronic lymphocytic leukemia and has similar morphology as de novo pro- lymphocytic leukemia. Complete remission in CLL/PL with prolymphocytic transformation might be obtained by fludarabine therapy.