| 377例双向分化恶性肿瘤血管生成拟态临床意义分析 |
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| 引用本文： | 孙保存,张诗武,倪春生,刘志勇,戚红,张丹芳.377例双向分化恶性肿瘤血管生成拟态临床意义分析[J].中国肿瘤临床,2005,32(2):64-67. |
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| 作者姓名： | 孙保存 张诗武 倪春生 刘志勇 戚红 张丹芳 |
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| 作者单位： | 天津市肿瘤医院,肿瘤研究所病理科,天津市,300060 |
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| 摘 要： | 目的:探讨双向分化恶性肿瘤组织中血管生成拟态的临床意义.方法:收集1955～2000年间我院病理科石蜡包埋双向分化恶性肿瘤样本887例,其中临床和病理资料完整的377例作为研究对象,分为有血管生成拟态组和无血管生成拟态组,分析具有血管生成拟态肿瘤的临床意义.结果:除滑膜肉瘤外(P=0.759),恶性黑色素瘤(P=0.038 2)、间皮肉瘤(P=0.035 6)、横纹肌肉瘤(P=0.028 2)中具有血管生成拟态的肿瘤患者生存时间明显低于无血管生成拟态肿瘤患者,两者比较差异有显著性.结论:具有血管生成拟态的双向分化恶性肿瘤恶性度高、血道转移早、临床预后差.
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| 关 键 词： | 双向分化恶性肿瘤 血管生成拟态 临床预后 |
| 文章编号： | 1000-8179(2005)02-0064-04 |
The Clinical Significance Study of Vasculogenetic Mimicry in 337 Cases of Bi-directional Differential Malignant Tumors |
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| Sun Baocun Zhang Shiwu Ni Chunsheng et alCancer Hospital of Tianjin Medical University,Tianjin.The Clinical Significance Study of Vasculogenetic Mimicry in 337 Cases of Bi-directional Differential Malignant Tumors[J].Chinese Journal of Clinical Oncology,2005,32(2):64-67. |
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| Authors: | Sun Baocun Zhang Shiwu Ni Chunsheng Cancer Hospital of Tianjin Medical University Tianjin |
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| Abstract: | Objective: To investigate the clinical significance of vascilogenic mimicry in bi-directional differential malignant tumours. Methods: Three hundred and seventy-seven cases of bi-directional differential malignant tumours, whose clinical and pathological data is adequate, were enrolled into our study. These tumors were divided into two groups, with vasculogenetic mimicry or non- vasculogenetic mimicry. The clinical significance of vasculogenic mimicry was assessed. Results: The prognosis of tumors with vasculogenetic mimicry in melanoma, rhabdomyosarcoma, mesothelial sarcoma except for synovial sarcoma were worse compared to the tumors without vasculogenic mimicry. Conclusion: Tumors with vasculogenic mimicry have a high-grade malignancy, early blood metastasis and poor clinical prognosis. |
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| Keywords: | Bi-directional differential malignant tumor Vasculogenic mimicry Clinical prognosis |
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