| 腺苷A2a受体在炎症反应中的作用 |
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| 引用本文： | 郦铮铮,郑荣远.腺苷A2a受体在炎症反应中的作用[J].国际免疫学杂志,2003,32(1):313-316. |
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| 作者姓名： | 郦铮铮 郑荣远 |
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| 作者单位： | 实验神经生物学研究所,温州医学院附属第一医院神经科,325000; |
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| 摘 要： | 腺苷广泛分布于全身各组织器官,可通过与细胞表面相应G-蛋白偶联受体结合发挥抑制炎症反应,对抗缺血/缺氧和免疫调节等生物学作用.目前发现腺苷受体有4种亚型,即A1R、A2aR、A2bR和A3R.其中A2a腺苷受体(A2aR)广泛分布于神经胶质细胞,巨噬细胞,树突状细胞,肥大细胞,自然杀伤细胞等免疫细胞及内皮细胞和上皮细胞中,在相应的腺苷配体作用下,可通过腺苷-腺苷受体系统介导炎症反应和发挥免疫调节作用.
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| 关 键 词： | 腺苷受体 腺苷 炎症反应 免疫调节 |
Effects of A2a adenosine receptor on inflammatory reaction |
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| Abstract: | Adenosine has a wide distribution in organs and tissues of the human body. It plays diverse physio-logical roles including the inhibition of inflammatory reactions, the resistance of ischemia/hypoxia and the mod-ulation of immunological reactions through binding with G-protein-coupled receptors on cell surfaces. There are four kinds of adenosine receptors, A1R,A2aR,A2bR and A3R. A2aR is widely expressed in virtually all cell typos involving in inflammatory/immune responses. These cell types include glial cells, macrophages, dendritic cells, mast cells, NK cells, endothelial cells, as well as epithelial cells. A2aR serves to regulate conventional inflammatory reactions and immunological reactions. |
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| Keywords: | A2a adenosine receptorsAdenosineInflammatory reactionImmunoloregulation |
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