nm23—H1过表达与乳腺癌和皮肤癌转移的相关性

目的：对比研究乳腺癌与皮肤癌转移抑制基因ｎｍ２３－Ｈ１表达的意义。方法：用单克隆抗体免疫组织化学Ｓ－Ｐ法检测８１例乳腺癌及１００便皮肤癌。ｎｍ２３－Ｈ１阳性细胞数超过３０％的癌细胞定为过度表达。结果：乳腺癌中导管原位癌、无转移及有转移浸润性导管癌的过表达率分别为８２％、７７％和３３％。皮肤癌中基底细胞癌、无转移及有转移鳞状细胞癌的过表达率分别为７９％、６１％和２７％，判别有显著意义Ｐ〈０．００５％

The significance of nm23-H1 overexpression in breast cancer and skin cancer

Purpose To compare the significance of nm23-H1 antimetastatic gene overexpression in breastcancer and skin cancer. Methods The expression of nm23-H1 was examined by using monoclonal antibody im-munohistochemical S-P method. Positive cancer cells over 30 % in a case was determined as overexpression. Re-sults In breast intraductal carcinoma, infiltrating ductal carcinoma without and with metastasis, the rates ofnm23-H1 overexpression were 82%, 77% and 33% respectively. In skin hasal cell carcinoma, squamous cellcarcinoma without and with metastasis, the rates of nm23-H1 overexpression were 79 %, 61 % and 27 % respectively. Conclusion The rates of nm23-H1 overexpression have similar features in breast cancers and in skin can-cers and effect on their metastatic control. Basal cell carcinoma is different from squamous cell carcinoma in bio-logic behavior, that is usual infiltration but rare metastasis. We reason out the answer to that hasal cell carcino-ma reserve high level of nm23-H1. Metastatic behavior may be principally controled by the antimetastatic gene.