| 低剂量甲基汞对小鼠胸腺和脾细胞周期进程的影响 |
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| 引用本文： | 李修义,刘洪宇.低剂量甲基汞对小鼠胸腺和脾细胞周期进程的影响[J].环境与健康杂志,1994,11(3):107-108. |
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| 作者姓名： | 李修义 刘洪宇 |
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| 作者单位： | 白求恩医科大学 |
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| 摘 要： | 雄性昆明小鼠连续饮用含甲基汞浓度为１／１０００ＬＤ５０,１／１００ＬＤ５０,１／５０ＬＤ５０和１／１０ＬＤ５０有自来水９０天,采用ＦＡＣＳｃａｎ流式细胞仪（ＦＣＭ）分析胸腺和脾细胞周期进程,发现除１／１０００ＬＤ５０剂量组外,其余各剂量组从Ｇ０／Ｇ１时相进入Ｓ时相的脾细胞百分数均明显高艰（Ｐ＜０．０５）,与染毒剂量呈明显天正相关,而胸腺细胞周期进程与对照组无明显差异。提示连续经口摄入低剂量甲基汞水
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| 关 键 词： | 低剂量甲基汞 胸腺 脾细胞 细胞周期进程 小鼠 |
Influence of Low Dose Methylmercury on Cell Cycle Progression of Thymocytes and Splenocytes in Mice |
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| Li Xiuyi,et al..Influence of Low Dose Methylmercury on Cell Cycle Progression of Thymocytes and Splenocytes in Mice[J].Journal of Environment and Health,1994,11(3):107-108. |
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| Authors: | Li Xiuyi |
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| Abstract: | Male Kunming mice drank continuously tap water contained methylmercury concentration in 1/ 1000LD_(50),1/ 100LD_(50),1/50LD_(50)and 1/10LD_(50) for 90 days.The cell cycle progression of thymocytes and splenocytes was analyzed by a FACScan flow cytometry with software"CELLFIT".It was found that the percentage of splenocytes with S phase from G0/G1 phase in those groups except 1/1000LD_(50)group was significantly higher than in control(P<0.05),correlated positively with contaminative dose.At the same condition,there was no obvious difference in the cell cycle progression of thymocytes from control.The results suggest that the DN A replication of splenocytes in mice was enhanced significantly by low dose methylmercury intaked continuously via the mouth. |
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| Keywords: | Low dose methylmercury Thymocytes Splenocytes Cell cycle progression |
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