超常胎盘部位临床病理及免疫组化分析

目的　研究超常胎盘部位 (EPS)的临床病理及免疫组化特点。方法　应用免疫组化SP法对 5例EPS病变进行研究 ,并结合临床表现进行病理分析。结果　EPS是中间型滋养细胞在胎盘部位非破坏性地浸润肌层和血管壁 ,不形成肿块 ,HPL、CK、PLAP强 ( )或 ( ) ,HCG弱 ( )或 (- ) ,Ki 6 7、p5 3均 (- )。结论　EPS与妊娠有关 ,是一个良性非肿瘤性病变 ,可导致产后大出血 ,明确诊断对临床有重要意义。

Clinical pathology and immunohistochemistry of exaggerated placental site

Objective To study the clinicopathologic and immu nohistochemical features of exaggerated placental site (EPS). Methods Five cases of EPS were investigated with light microscope level an d by immunohistochemical staining and analysis of clinical sympto ms. Results EPS was that intermediate trophoblast (IT) infiltr ated understructively into the myometrium layers and wall of the vessel in the placental site but no tumour formed. Cytokeratin and placental alkaline pho sphatase were strongly positive. HCG was weakly posit ive or negative, and Ki-67, p53 were negative. Conclusion EPS is correlated with pregnancy.It is benign pathological changes, but can lead to the s eriuos bleeding in postpartum, and it is important to make a defin ate diagnosis for clinical management.