The Effect of Platelet‐Rich Plasma on Healing of Palatal Donor Site following Connective Tissue Harvesting: A Pilot Study in Dogs |
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| Authors: | Yadollah Soleimani Shayesteh DDS Nosratollah Eshghyar DDS Neda Moslemi DDS Mohammad Mehdi Dehghan DVM PhD Pouria Motahhary DDS Zahra Ghobadi DMD Banafsheh Golestan PhD |
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| Affiliation: | 1. Periodontist, associate professor, Department of Periodontics, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran;2. oral pathologist, associate professor, Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran;3. periodontist, assistant professor, Department of Periodontics, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. veterinary surgeon, associate professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;5. oral pathologist, assistant professor, Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran;6. dentist, private practice, Tehran, Iran;7. statistician, assistant professor, Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Background: Peri‐implant plastic surgery includes soft tissue enhancement by connective tissue grafting. The palatal donor site provides peri‐implant keratinized mucosa and soft tissue height. Platelet‐rich plasma (PRP) contains growth factors that may enhance early healing. Purpose: The present animal study investigated the effect of PRP on wound healing of palatal donor site after connective tissue harvesting. Materials and Methods: In 12 mongrel dogs, bilateral palatal connective tissues of 10 × 15 mm were harvested. At test site, PRP was applied into the wound, and the contralateral site served as control. The healing was evaluated clinically and histologically at 1 week, 2 weeks, and 4 weeks after surgeries. Exact binomial probability and Wilcoxon signed‐rank test were used to compare the clinical and histologic measurements. Results: No statistically significant differences between PRP and control sites were measured with regard to clinical healing (p = 1.000) and histologic variables, including inflammatory cells (p = .750), collagen fibers (p = .375), and granulation tissue (p = .500) at any time interval. Conclusion: The addition of PRP to palatal mucosal wound sites did not accelerate wound healing. |
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| Keywords: | connective tissue graft histologic study palatal donor site platelet‐rich plasma soft tissue augmentation wound healing |
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