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糖苷类化合物非水相生物催化结构修饰的研究进展
引用本文:杨荣玲,吴婷婷,赵祥杰,聂泽坤,王朝宇.糖苷类化合物非水相生物催化结构修饰的研究进展[J].生物质化学工程,2020,54(3):54-60.
作者姓名:杨荣玲  吴婷婷  赵祥杰  聂泽坤  王朝宇
作者单位:淮阴工学院 生命科学与食品工程学院, 江苏 淮安 223003
基金项目:江苏省"六大人才高峰"高层次人才项目;国家自然科学基金;江苏省自然科学基金青年项目
摘    要:介绍了非水相生物催化的现状,包括常用催化剂种类如游离酶、固定化酶和全细胞催化剂,常见的非水相催化介质如有机溶剂体系、无溶剂体系、离子液体体系以及超临界流体介质体系,阐述了糖苷类化合物的去糖基化修饰、糖基化修饰、酰化修饰以及甲基化修饰等方法,并叙述了结构修饰对化合物性质的影响,如提高化合物的溶解度、增强化合物的稳定性以及提升化合物的生物活性等,简单介绍了目前糖苷类结构修饰化合物的相关应用。

关 键 词:非水相  生物催化  糖苷类化合物  结构修饰  进展  
收稿时间:2019-06-25

Development of Structural Modification of Glycoside Compounds with Biological Catalyst in Non-aqueous Phase
Rongling YANG,Tingting WU,Xiangjie ZHAO,Zekun NIE,Zhaoyu WANG.Development of Structural Modification of Glycoside Compounds with Biological Catalyst in Non-aqueous Phase[J].Biomass Chemical Engineering,2020,54(3):54-60.
Authors:Rongling YANG  Tingting WU  Xiangjie ZHAO  Zekun NIE  Zhaoyu WANG
Affiliation:Huaiyin Institute of Technology, School of Life Science and Food Technology, Huai'an 223003, China
Abstract:This paper introduced the present situation of biological catalysis in non-aqueous phase. The common biological catalysts including free enzyme, immobilized enzyme and whole cell catalyst were presented in detail. Four kinds of catalytic media in non-aqueous phase including organic solvent system, solvent-free system, ionic liquid system and supercritical fluid medium system were described. And the deglycosylation, glycosylation, acylation modifications and methylation of glycoside compounds were expounded. This paper also described the effects of structural modification on the properties of the compounds, such as improving the solubility, enhancing the stability and promoting the biological activity of these compounds. The related applications of glycoside compounds with structural modification were briefly introduced.
Keywords:non-aqueous phase  biocatalytic  glycoside compounds  structural modification  advance  
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