| 球型脂联素对高糖环境NIT-1胰岛β细胞功能的影响 |
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| 引用本文： | 周嘉,李焱,杨川,徐明彤,李芳萍,严励,程桦,傅祖植.球型脂联素对高糖环境NIT-1胰岛β细胞功能的影响[J].中华内分泌代谢杂志,2007,25(1):316-317. |
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| 作者姓名： | 周嘉 李焱 杨川 徐明彤 李芳萍 严励 程桦 傅祖植 |
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| 作者单位： | 广西医科大学第一附属医院内分泌科;中山大学附属第二医院内分泌科,广州,510120; |
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| 摘 要： | 用β细胞株NIT-1来研究球型脂联素对高糖损伤β细胞分泌功能及相关基因表达的影响.结果 显爪球型脂联素可恢复部分β细胞功能相关基因的表达,抑制高糖诱导NAD(P)H氧化酶组分p47phox表达增加,但未能改善高糖诱导的胰岛素mRNA水平下降及胰岛素分泌缺陷.
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| 关 键 词： | NIT-1β细胞株 球型脂联素 NAD(P)H氧化酶 |
Effect of globular adiponectin on the function of NIT-I cells under high glucose medium |
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| ZHOU Jia,LI Yan,YANG Chuan,XU Ming-tong,LI Fang-ping,YAN Li,CHENG Hua,FU Zu-zhi.Effect of globular adiponectin on the function of NIT-I cells under high glucose medium[J].Chinese Journal of Endocrinology and Metabolism,2007,25(1):316-317. |
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| Authors: | ZHOU Jia LI Yan YANG Chuan XU Ming-tong LI Fang-ping YAN Li CHENG Hua FU Zu-zhi |
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| Abstract: | The effect of globular adiponectiin (gAd)on the function of NIT-1 cells under high glucose medium was investigated. The results showed that gad could completely block the increase of NADPH oxidase components p47phox expression and recover mRNA expression of pancreatic duodenal homeobox-I ,paired box gene 6,glucose transpoter 2,and glucokinase except neurogenic differentiation factor 1 (P<0.05 or P<0.01). Whereas,impaired insulin secretion and mRNA expression at high glucose concentration were not significantly improved by gAd. |
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| Keywords: | NIT-I cell linesGlobal adiponectinNAD(P) H oxidase |
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