| 解偶联蛋白2基因-866G/A,Ala55Val及Ins/Del多态性与宁夏回族人群脑缺血发病风险的相关性研究 |
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| 引用本文： | 金毅然,孙文青,马斌武,韩怀钦,牛建国,梁雪云,何仲义.解偶联蛋白2基因-866G/A,Ala55Val及Ins/Del多态性与宁夏回族人群脑缺血发病风险的相关性研究[J].卒中与神经疾病,2018,25(2):131-133+141. |
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| 作者姓名： | 金毅然 孙文青 马斌武 韩怀钦 牛建国 梁雪云 何仲义 |
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| 作者单位： | 750004 银川,宁夏医科大学总医院宁夏人类干细胞研究所[金毅然 梁雪云(通信作者)],神经内科(马斌武); 宁夏医科大学临床医学院[孙文青(共同第一作者)]; 宁夏医科大学基础医学院人体解剖与组织胚胎学系[韩怀钦 何仲义(通信作者)]; 宁夏颅脑疾病重点实验室(牛建国) |
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| 摘 要： | 目的 探讨UCP2基因多态性在回族人群中的分布特点及UCP2SNP与脑缺血发病风险的相关性。方法 收集宁夏地区回族正常人群及回族脑缺血患者外周血样本,提取外周血基因组DNA,采用聚合酶链反应-限制性片断长度多态性方法检测各样本UCP2基因-866G/A,Ala55Val及Ins/Del多态性。结果 UCP2基因-866G/A,Ala55Val及Ins/Del多态性在宁夏地区回族正常人群与脑缺血患者中分布频率无明显差异(P>0.05)。结论 UCP2多态性与宁夏地区回族脑缺血发病无相关性。
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| 关 键 词： | 解偶联蛋白2 基因多态性 回族人群 脑缺血 |
Associationstudy between single nucleotide polymorphism of UCP2 -866G/A,Ala55Val,Ins/Del and cerebral ischemia stroke attack in ningxia hui population |
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| Jin Yiran,Sun Wenqing,Ma Binwu,et al..Associationstudy between single nucleotide polymorphism of UCP2 -866G/A,Ala55Val,Ins/Del and cerebral ischemia stroke attack in ningxia hui population[J].Stroke and Nervous Diseases,2018,25(2):131-133+141. |
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| Authors: | Jin Yiran Sun Wenqing Ma Binwu |
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| Affiliation: | *Ningxia Human Stem Cell Research Institution,General Hospital of Ningxia Medical University,Yinchuan 750004 |
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| Abstract: | ObjectiveTo explore the features of UCP2 gene polymorphism distribution of people from Hui minority in Ningxia,and the association between single nucleotide polymorphism of Uncouple protein 2(UCP2)-866G/A,Ala55Val,Ins/Del and cerebral ischemia stroke attack.Methods After extracted genomic DNA from the collected peripheral blood in patients with cerebral ischemia and the normal,the PCR-RELF method was utilized to test the single nucleotide polymorphism of UCP2-866G/A,Ala55Val,Ins/Del.Results There was no statistical difference about the frequencies of single nucleotide polymorphism of UCP2-866G/A,Ala55Val,Ins/Del between the normal control group and the stroke group in Ningxia Hui population.Conclusion This study reveals that there is no relationship between single nucleotide polymorphism of UCP2-866G/A,Ala55Val,Ins/Del and cerebral ischemia stroke attack in Ningxia Hui population. |
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| Keywords: | Uncouple protein 2 Single nucleotide polymorphism Hui population Cerebral ischemia stroke |
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