替米沙坦治疗高血压肾病的临床研究

目的研究替米沙坦（邦坦）治疗高血压肾病患者的作用效果。方法将40例高血压肾病患者随机分成两组，治疗组给予口服替米沙坦（邦坦）治疗，对照组给予口服缬沙坦治疗，观察用药前后血压、尿蛋白、尿素氮、肌酐的变化，治疗前后血常规，肝、肾功能，空腹血糖，血电解质、血脂和心电图的变化，数据采用t检验。结果两组患者血压较治疗前均显著降低，治疗组血压的降低较对照组比显著减低P〈0．05；治疗组尿蛋白定量减少、尿素氮、肌酐减低比对照组明显（P〈0．05），且治疗后比治疗前明显降低（P〈0．05）。结论替米沙坦（邦坦）可有效降压、减少蛋白尿，保护肾功能，延缓高血压肾损害的进展。

Clinical Study on Hypertension Nephropathy with Telmisartan

Objective To study the curative effect on hypertension nephropathy treated with telmisartan.Methods 40 cases of such patient were divided into two groups randomly.The therapy group was treated with telmisartan and control group was treated with valsartan.The changes of Bp,urine protein,BUN,creatinine,blood routine test as liver and kidney function,electrolyte,lipid and ECG were observed before and after treatment.The t test was analyzed.Results The Bp was decreased in both group and more obviously in therapy group with significant difference P<0.05.The urine protein,BUN and creatinine in therapy grup were decreased obviously after treatment with P<0.05.Conclusion The telmisartan might decrease blood pressure and urine protein to protect renal function and delay the progress of hypertension.