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| 肝脂酶基因-250G/A多态性与腔隙性脑梗死的关系 | |
| 引用本文： | 陈李芳,谭利明,肖志杰,聂赛,谢湘竹,韩漫夫.肝脂酶基因-250G/A多态性与腔隙性脑梗死的关系[J].中国动脉硬化杂志,2011,19(8):688-692. |
| 作者姓名： | 陈李芳 谭利明 肖志杰 聂赛 谢湘竹 韩漫夫 |
| 作者单位： | 1. 广东省深圳市第二人民医院神经内科,广东省深圳市,518035 2. 中南大学湘雅二医院神经内科,湖南省长沙市,410011 3. 中南大学湘雅二医院心内科,湖南省长沙市,410011 |
| 摘 要： | 目的探讨肝脂酶基因(LIPC)-250G/A多态性与腔隙性脑梗死的关系。方法采用病例对照研究,筛选152名腔隙性脑梗死患者及108名正常对照组人群为研究对象。采用聚合酶链反应-单核苷酸多态性方法测定LIPC-250G/A基因多态性。结果在腔隙性脑梗死人群中,LIPC-250G/A基因型分布为GG 51.32%、GA 36.84%和AA 11.84%,等位基因G和A的分布频率分别为0.697和0.303。GA型和AA型的血浆高密度脂蛋白胆固醇水平显著高于GG型(P<0.05)。LIPC-250G/A基因型和等位基因频率分布在腔隙性脑梗死组与对照组中之间差异无显著性(P>0.05)。结论 LIPC-250G/A多态性产生有益的临床血脂谱,但可能与腔隙性脑梗死发病无关。 |
| 关 键 词： | 肝脂酶 基因 多态性 单核苷酸 腔隙性脑梗塞 |
| 收稿时间： | 2011/3/14 0:00:00 |
The Relationship between Polymorphism of Hepatic Lipase Gene-250G/A Polymorphism and Lacunar Infarction |
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| CHEN Li-Fang,TAN Li-Ming,XIAO Zhi-Jie,NIE Sai,XIE Xiang-Zu,HAN Man-Fu.The Relationship between Polymorphism of Hepatic Lipase Gene-250G/A Polymorphism and Lacunar Infarction[J].Chinese Journal of Arteriosclerosis,2011,19(8):688-692. | |
| Authors: | CHEN Li-Fang TAN Li-Ming XIAO Zhi-Jie NIE Sai XIE Xiang-Zu HAN Man-Fu |
| Affiliation: | CHEN Li-Fang1,TAN Li-Ming2,XIAO Zhi-Jie2,NIE Sai3,XIE Xiang-Zu3,HAN Man-Fu1(1.Department of Neurology,Shenzhen Second Hospital,Shenzhen,Guangdong 518035,China,2.Department of Neurology,Xiangya Second Hospital,Central South University,Changsha,Hunan 410011,3.Department of Cardiology,China) |
| Abstract: | Aim To explore the relationship between hepatic lipase gene(LIPC)-250G/A polymorphism and lacunar infarction(LI). Methods A case-control study was performed in 152 patients with LI and 108 healthy controls.The polymerase chain reaction-single nucleotide polymorphism(PCR-SNP) was used to determine the LIPC-250G/A polymorphism. Results The LIPC-250G/A genotype distribution in patients with LI was GG 51.32%,GA 36.84% and AA 11.84%,respectively.Allele frequencies for G and A were 0.697 and 0.303 respectively.Th... |
| Keywords: | Hepatic Lipase Gene Polymorphism Single Nucleotide Lacunar Infarction |
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