| 甲状腺素及促甲状腺素对骨转换作用机制的研究进展 |
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| 引用本文： | 杜敏群,胡卓清,崔燎.甲状腺素及促甲状腺素对骨转换作用机制的研究进展[J].中国骨质疏松杂志,2018(2):259-263. |
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| 作者姓名： | 杜敏群 胡卓清 崔燎 |
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| 作者单位： | 广东医学院药理学教研室;广东天然药物研究与开发重点实验室; |
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| 基金项目： | 国家自然科学基金项目（81273518）；广东省科学计划项目（2012B060300027）；
广东医学院科技创新基金项目（STZF101104） |
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| 摘 要： | 甲状腺功能亢进症是引起继发性骨质疏松症的危险因素。目前关于甲亢导致的骨质疏松机制还不完全明了,但过量甲状腺素会对骨转换产生影响,促甲状腺素水平的降低可能也参与其中。本文综述甲状腺素、促甲状腺素对骨转换作用机制的研究,为以后甲亢性骨质疏松病因机制研究提供新思路。
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| 关 键 词： | 甲状腺素 促甲状腺素 骨质疏松 骨转换 成骨细胞 破骨细胞 |
Advances on the effect and mechanism of thyroxine and thyrotropin on bone turnover |
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| DU Minqun,HU Zhuoqing,CUI Liao.Advances on the effect and mechanism of thyroxine and thyrotropin on bone turnover[J].Chinese Journal of Osteoporosis,2018(2):259-263. |
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| Authors: | DU Minqun HU Zhuoqing CUI Liao |
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| Affiliation: | 1. Department of Pharmacology, Guangdong Medical College, Zhanjiang, Guangdong 524023
2. Guangdong Key Laboratory for Research and Development of Natural Drugs, Zhanjiang, Guangdong 524023, China |
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| Abstract: | Hyperthyroidism is a risk factor for secondary osteoporosis. Currently the mechanism of osteoporosis caused by hyperthyroidism is still not fully understood, but excessive thyroxine may affect bone turnover, and lower level of thyrotropin may also play a role. This article reviews research on the effect and mechanism of thyroxine and thyrotropin on bone turnover, with the aim of providing new ideas for studying the mechanism of hyperthyroidism induced osteoporosis. |
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| Keywords: | Thyroxine Thyrotropin Osteoporosis Bone turnover Osteoblast Osteoclast |
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