| 腋淋巴结转移阳性乳腺癌新辅助化疗临床意义的探讨 |
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| 引用本文： | 黄欧,陈灿铭,胡震,柳光宇,吴炅,陆劲松,狄根红,邵志敏,沈镇宙,沈坤炜.腋淋巴结转移阳性乳腺癌新辅助化疗临床意义的探讨[J].中华肿瘤防治杂志,2009,16(24):1939-1941. |
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| 作者姓名： | 黄欧 陈灿铭 胡震 柳光宇 吴炅 陆劲松 狄根红 邵志敏 沈镇宙 沈坤炜 |
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| 作者单位： | 1. 上海交通大学医学院附属瑞金医院外科,上海,200025
2. 复旦大学附属肿瘤医院乳腺外科,上海,200032 |
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| 摘 要： | 目的:探讨新辅助化疗对经细针针吸活检证实有腋窝淋巴结癌转移局部晚期乳腺癌的影响.方法:111例局部晚期乳腺癌经细针针吸活检确诊有腋窝淋巴结癌转移且空心针穿刺确诊为浸润性乳腺癌,接受≥2个周期标准剂量新辅助化疗后手术治疗.根据新辅助化疗后不同的腋窝淋巴结临床疗效和腋窝淋巴结病理状况,分组进行生存分析.结果:新辅助化疗后,腋窝淋巴结临床完全缓解(cCR)占60.4%(67/111),其中腋窝淋巴结病理完全缓解(pCR)占29.9%(20/67);未临床完全缓解(no-cCR)占39.6%(44/111),其中PeR占36.4%(16/44).中位随访时间为65个月(13～76个月).cCR与no-cCR两组的无病生存时间(DFS)和总生存时间(OS)差异均无统计学意义,P值分别为0.182和0.984.pCR患者具有较长DFS和OS,P值分别为0.036和0.038.pCR患者中,肿瘤原发灶pCR与no-pCR患者的DFS和OS差异均无统计学意义,P值分别为0.204和0.250.结论:对病理学确诊有腋窝淋巴结癌转移的局部晚期乳腺癌患者,单纯根据临床体检结合常规的腋窝B超检查评价腋窝淋巴结的临床疗效,可能难以准确地预测腋窝淋巴结的病理缓解状况和预后.腋窝淋巴结pCR患者的预后较好,与肿瘤原发灶是否达到pCR无关.
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| 关 键 词： | 乳腺肿瘤/药物疗法 淋巴转移 预后 |
Effect of neoadjuvant chemotherapy in treatment of locally advanced breast cancer with cytologically proven axillary node metastases |
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| HUANG Ou,CHEN Can-ming,HU Zhen,LIU Guang-yu,WU Jiong,LU Jin-song,DI Gen-hong,SHAO Zhi-min,SHEN Zhen-zhou,SHEN Kun-wei.Effect of neoadjuvant chemotherapy in treatment of locally advanced breast cancer with cytologically proven axillary node metastases[J].Chinese Journal of Cancer Prevention and Treatment,2009,16(24):1939-1941. |
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| Authors: | HUANG Ou CHEN Can-ming HU Zhen LIU Guang-yu WU Jiong LU Jin-song DI Gen-hong SHAO Zhi-min SHEN Zhen-zhou SHEN Kun-wei |
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| Affiliation: | HUANG Ou1,CHEN Can-ming2,HU Zhen2,LIU Guang-yu2,WU Jiong2,LU Jin-song2,DI Gen-hong2,SHAO Zhi-min2,SHEN Zhen-zhou2,SHEN Kun-wei1 1.Department of Surgery,Ruijin Hospital,School of Medicine,Shanghia Jiao Tong University,Shanghai 200025,P.R. China2.Department of Breast Surgery,Cancer Hospital,Fudan University,Shanghai 200032,P.R. China |
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| Abstract: | OBJECTIVE:To evaluate the effect of neoadjuvant chemotherapy (NC) on locally advanced breast cancer with cytological proven axillary lymph node (ALN) metastases by fine needle biopsy. METHODS:From January 2000 to May 2006,111 patients with cytological proven ALN metastases by fine needle biopsy were identified,and these patients had received at least two cycles of NC in the standard dosage. The relationship between the clinical and pathological responses of ALN with disease-free survival (DFS) and overall s... |
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| Keywords: | breast neoplasm/drug therapy lymphatic metastasis prognosis |
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