P53、C-erbB-2和VEGF在胃癌中的表达及其临床意义

：目的]分析P53、C-erbB-2、VEGF在胃癌组织中的表达与胃癌临床病理特征之间的关系.方法]收集我院2006年1月-2007年12月经手术切除且病理证实的胃癌病例,记录各患者分化程度、浸润程度、淋巴结转移情况及TNM分期.获得临床资料完整的病例60例,复习病理大体及镜下特点,行免疫组化染色,观察P53、C-erbB-2、VEGF在胃癌组织中的表达情况.结果]（1）P53基因蛋白在胃癌组织中表达阳性率为60%,P53基因蛋白阳性表达与分化程度、有无淋巴结转移有关.（2）C-erbB-2基因蛋白在胃癌组织中表达阳性率为73.3%.C-erbB-2基因蛋白阳性表达与与浸润程度及淋巴结是否转移有关）.（3）VEGF在胃癌组织中表达阳性率为75%.VEGF阳性表达与浸润深度、淋巴结是否转移及临床分期有关.结论]联合检测P53、C-erbB-2及VEGF在胃癌组织中的表达对胃癌的临床诊断、病情评估、治疗及预后可提供一定指导.

Expression of P53,C-erbB-2 and VEGF in gastric cancer and the clinical significance

Objective] By analyzing the relationship between P53, C-erbB-2 and VEGF expression in gastric cancer and clinical features of gastric cancer,to help accurate determination the patient＇s condition and prognosis. Methods] By collecting surgically reseeted and pathologically confirmed cases of gastric cancer,get 60 cases of complete clinical data. To observe P53, C-erbB-2 and VEGF expression in gastric cancer, and to analyse by using SPSS 10.0 statistical software. Results] Positive rate of P53 gene expression in gastric cancer was 60%. P53 gene expression was positively correlated with the differentiation and lymphaden metastases. Positive rate of C-erbB-2 gene expression in gastric cancer was 73.3 %. C-erbB-2 gene expression was positively correlated with the extension and lymphaden metastases. Positive rate of VEGF expression in gastric cancer was 75 % .VEGF expression was positively correlated with the extension, lymphaden metastases and clinical stages. Conclusion] Combined detection of the expression of P53, C-erbB-2 and VEGF in gastric cancer may give some guideline for the clinical diagnosis ,illness evaluation ,treatment and prognosis of gastric cancer.