Preoperative staging of biliary carcinoma using 18F-fluorodeoxyglucose PET: prospective comparison with PET+CT, MDCT and histopathology |
| |
Authors: | Hiroyoshi Furukawa Hiroki Ikuma Koiku Asakura-Yokoe Katsuhiko Uesaka |
| |
Affiliation: | (1) Division of Diagnostic Radiology, Shizuoka Cancer Center Hospital, 1007, Nagaizumi-cho, Suntogun, Shizuoka 411-8777, Japan;(2) Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan |
| |
Abstract: | The aim of this study was to evaluate the value of positron emission tomography with 18F-labeled fluorodeoxyglucose (FDG-PET) as a preoperative diagnostic investigation in patients with biliary carcinoma. Seventy-two
patients with potentially resectable biliary carcinoma underwent preoperative multidetector-row computed tomography (MDCT)
and FDG-PET. Both diagnoses were compared with subsequent histopathology and follow-up results. In 64 lesions with biliary
carcinoma, 57 (89%) revealed an intense focal accumulation on FDG-PET and were interpreted as malignant. On the other hand,
eight benign lesions did not show any specific accumulation. Detection rate of FDG-PET in the nodular type of the tumour (96%
or 27/28) was superior to that of the infiltrating type (74% or 17/23) (p = 0.037). For the evaluation of lymph node metastasis, the overall accuracy was 69% (35/51) in both FDG-PET and MDCT: FDG-PET
had a lower sensitivity (33% vs. 57%) and a higher specificity (97% vs. 79%) than MDCT, although the values were not significantly
different. FDG-PET revealed all six lesions of distant metastases in six patients including two lesions missed by MDCT. FDG-PET
has high detectability of biliary malignancies. Like MDCT, FDG-PET offers only modest accuracy for regional lymph node staging,
but it may reveal distant metastases missed by MDCT. |
| |
Keywords: | Positron emission tomography Biliary neoplasms Spiral computed tomography Neoplasm staging Biliary surgery |
本文献已被 PubMed SpringerLink 等数据库收录! |
|