中药有效成分Vam3对小鼠气道非特异性炎症模型T_H1/T_H2应答的调节作用

本研究的目的是利用气道炎症小鼠模型来探讨中药有效成分Vam3调节气管炎症的免疫平衡的效果。小鼠用伴清蛋白腹膜内致敏,然后气管内发敏。在首次发敏后24h用中药有效成分Vam3进行治疗。用地塞米松治疗组、生理盐水组及不作处理的空白对照组作为对照。中药有效成分Vam3的评价主要是对抗原特异性抗体的产生及产生细胞因子类型的影响。结果显示,与盐水对照组相比,中药有效成分Vam3可有效减少抗原特异性IgE、IL-4、IL-5和IL-13的水平,而IgG2和IFN-γ合成不受抑制。证实其有抗气道炎症和调节TH1/TH2应答类型的作用,可用于气道炎症的治疗。

The effect of active principle Vam3 switch TH1/TH2 balance in inflammatory airway murine model

The goal of this study was to investigate the effects of the Chinese herbal medicine active principle Vam3,derived from TCMs used to treat airway inflammation,on a well-characterized mouse model of inflammatory airway.,view the effects of immunity balance in inflammatory airway modal.Mice sensitized intraperi toneally and challenged intratracheally with conalbumin were treated with Vam3 24 hours after the first intratracheal challenge.Dexamethasone-treated,saline solution sham-treated,and nave mice served as controls.The effects of Vam3 on inflammation,antigen-specific antibody production and cytokine profiles were evaluated.Vam3 treatment showed that it can decreased antigen-specific IgE,IL-4,IL-5,and IL-13 levels without suppressing IgE2a and IFN-γ synthesis.Approve that Vam3 can decrease airway inflammation and tune up TH1/TH2 immunity balance,clue to it can treats airway inflammation.