| 聚乳酸材料的仿生修饰研究进展 |
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| 引用本文： | 周熙云,王远亮.聚乳酸材料的仿生修饰研究进展[J].材料导报,2009,12(23). |
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| 作者姓名： | 周熙云 王远亮 |
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| 作者单位： | 重庆大学生物工程学院生物材料与仿生工程研究中心,生物流变科学与技术教育部重点实验室,重庆,400030 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 聚乳酸是生物可降解、生物相容性材料,但由于存在亲水性差、缺乏细胞识别位点等缺陷,限制了其在生物医学工程中的应用.模拟细胞与基质相互作用的特点以及细胞外基质的特性,通过表面修饰、本体改性和复合加工的方法在聚乳酸中引入蛋白胶原、活性肽、多糖以及羟基磷灰石等生物活性分子,实现聚乳酸的仿生修饰,能够有效提高聚乳酸材料的生物学功能.综述了利用这些生物活性分子对聚乳酸进行仿生修饰的研究进展.
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| 关 键 词： | 聚乳酸 仿生 表面修饰 本体改性 复合 |
Progress of Bio-inspired Modification of Polylactides |
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| ZHOU Xiyun,WANG Yuanliang.Progress of Bio-inspired Modification of Polylactides[J].Materials Review,2009,12(23). |
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| Authors: | ZHOU Xiyun WANG Yuanliang |
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| Affiliation: | ZHOU Xiyun,WANG Yuanliang (National 985 Research Center of Bio-inspired Material Science , Engineering,Bioengineering College,Key Laboratory of Biorhelogical Science , Technology of the Ministry of Education,Chongqing University,Chongqing 400030) |
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| Abstract: | Polylactides have good biodegradability and biocompatibility,but poor hydrophilicity and lack of cell recognition sites.Their applications in biomedicine engineering have been limited.Mimicking cell-matrix interaction and the properties of extracellular matrix(ECM),bio-inspired modification of polylactides has been achieved by surface modification,bulk modification and composition with bioactive molecules such as collagen,short peptide sequences derived from intact ECM proteins,polysaccharides,as well as hy... |
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| Keywords: | polylactides bio-inspired surface modification bulk modification composition |
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