IVIM-DWI模型各参数与乳腺癌预后因子及分子亚型的相关性分析

目的 探讨 IVIM-DWI模型各参数与乳腺癌预后因子及分子亚型的相关性。方法 回顾性分析我院152例乳腺癌患者DCE-MRI及IVIM-DWI资料,获得病灶IVIM-DWI参数(f值、D值、D^*值)及预后因子(ER、PR、HER-2、Ki-67)的表达情况以分析IVIM-DWI各参数与各预后因子的相关性;根据病灶的免疫组化结果确定各病灶的分子亚型,分析IVIM-DWI各参数与分子亚型的相关性。结果 D值、D^*及f值在ER阳性、阴性组间的差异均无显著统计学意义;D值与PR受体、HER2受体及Ki-67的表达均呈弱负相关;而D^*值与HER-2表达阳性呈正相关。Luminal A型乳腺癌的D值最高,且与其他三型乳腺癌组之间的差异均具有统计学意义;三阴性乳腺癌的D值最低,与Luminal A及HER-2过表达各组之间的差异均有统计学意义,与Luminal B型之间的差异无统计学意义。D值在Luminal B型及HER-2过表达型之间的差异具有统计学意义; D^*值及f值在各分子亚型之间的差异无统计学意义。结论 D值与PR受体、HER-2受体及Ki-67的表达有一定的相关性;并且D值在区分不同分子亚型乳腺癌方面具有潜在的价值。

Correlation analysis among parameters of IVIM-DWI model,prognostic factors and molecular subtypes of breast cancer

Objective To explore the correlation analysis among the parameters of IVIM-DWI model and the prognostic factors and molecular subtypes of breast cancer. Methods The DCE-MRI and IVIM-DWI data of 152 patients with breast cancer were retrospective analyzed, the parameters of IVIM-DWI (f value, D value and D^* value) and the expression of prognostic factors (ER, PR, HER-2, Ki-67) were used to analyze the correlation among IVIM-DWI parameters and prognostic factors. The molecular subtypes of the lesions were determined by the immunohistochemical Results and then the correlations between the IVIM-DWI parameters and molecular subtypes were analyzed. Results There was no significant difference of D value, D^*value and f value between the ER positive and negative groups. The D value was negatively correlated with the expression of PR, HER-2 receptors and Ki-67. The D^* value was positive correlated with the expression of HER-2. The D value of the Luminal A type group was significantly higher than that of the other groups; The D value of the triple negative breast cancer was the lowest among of them, there was significant difference of Luminal A type and HER overexpression, however, there was no significant difference between the triple negative breast cancer and the Luminal B type. D^* value and f value had no significant difference among the molecular subtypes. Conclusion The D value had some correlation with PR, HER-2 receptors and Ki-67 expression. And the D value might have a potential value in distinguishing different molecular subtypes of breast cancer.