乳腺癌组织中HER-2的表达及其药物治疗策略

目的 探讨乳腺癌组织中HER-2的表达与患者组织学类型、TNM分期、腋窝淋巴结转移、ER和PR间的关系,及HER-2过度表达乳腺癌的药物治疗策略.方法 用免疫组织化SP法检测311例乳腺癌组织HER-2的表达.结果 1、HER-2阳性表达87例(占27.97%).2、HER-2的表达与组织学类型、TNM分期无关(P值分别为0.157和0.256).3、HER-2阳性表达与腋窝淋巴结转移、ER和PR表达降低有关(P值分别为0.032,0.014和0.026).结论 乳腺癌患者HER-2过表达提示预后不良,检测该指标可为化疗、内分泌、靶向治疗提供依据.

Expressions of HER-2 in breast cancer and strategy of drug treatment

OBJECTIVE To study the expressions of human epidermal growth factor recepter 2(HER-2) in breast cancer tissues and their clinical significance,strategy of drug treat.METHODS The expressions of HER-2 were detected by immunohistochemistry in 311 cases of breast cancer tissues proved pathologically.RESULTS 1.The positive rates of HER-2 was 27.97% in breast cancer tissues.2.Significant relationships were found among the expressions of HER-2 with axillary nodes metastasis,ER and PR lose status of breat cancer(P=0.032,0.014 and 0.026).3.The associations among the expression of HER-2 with TNM status,histologic group did not reach statistical significance.CONCLUSION Those findings indicate that overexpression of HER-2 is one of unfavorable prognosis index.The endocrine therapy,targeted therapy and chemotherapy of breast cancer may according to it.